IP Library Granted Patent US 7,420,042
Granted Patent B2
US 7,420,042 · App. 10/303,786 · Granted Sep 2, 2008

Soluble neuropilin/growth factor receptor fusion proteins

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Quick Facts
Patent No.
US 7,420,042
App. No.
10/303,786
Granted
Sep 2, 2008
Kind
B2
Abstract

Complexes of a protein selected from the group consisting of VEGF-B 167 , VEGF-C, VEGF-D and processed VEGF-B 186 and analogs thereof and the neuropilin-1 (NP-1) receptor, the extracellular domain or a ligand-binding fragment or analogue thereof; the use of such complexes in assays for growth factor proteins having substantially the same binding affinity for a cell surface receptor as VEGF-B 167 , VEGF-C, VEGF-D or processed VEGF-B 186 and/or in promoting or antagonizing a cellular response mediated by VEGF-B 167 , VEGF-C, VEGF-D and/or processed VEGF-B 186 ; and specific binding partners, e.g. antibodies, for such complexes.

Claims (5)

1. A fusion protein comprising at least a first protein domain and a second protein domain, the first domain comprising the amino acid sequence encoded by exon 6B of VEGF-B 167 , and the second domain being selected from VEGF 165 , VEGF-C, VEGF-D and processed VEGF-B 186 .

2. The fusion protein of claim 1 wherein the second protein domain is VEGF 165 .

3. The fusion protein of claim 1 wherein the second protein domain is VEGF-C.

4. The fusion protein of claim 1 wherein the second protein domain is VEGF-D.

5. The fusion protein of claim 1 wherein the second protein domain is processed VEGF-B 186 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 14, 2007
From: LUDWIG INSTITUTE FOR CANCER RESEARCH; LICENTIA LTD.
To: VEGENICS LIMITED
Reel/Frame 020243/0259 →