Erythropoietin dosing regimen for treating anemia
View Patent ↗The present invention provides a new subcutaneous injection dosing regimen for erythropoietin to treat anemia. The new erythropoietin treatment regimen of the present invention results in improved hemoglobin levels with less frequent dosing.
1. A method of raising and maintaining the hemoglobin levels in a patient comprising:
a) administering an effective amount of about 5,000 IU/kg of erythropoietin to a patient by a subcutaneous injection once every week until a hemoglobin increase of about 2 g/dL is achieved; and
b) after achieving the hemoglobin increase of step (a), administering, by subcutaneous injection once every two weeks, an amount that is greater than the amount administered in step (a), such that a hemoglobin level within about 1 g/dL of that achieved in step (a) is maintained.
2. The method of claim 1 , wherein said erythropoietin administered in step (b) is in an amount of 17,000 to 25,000 IU/kg.
3. The method of claim 1 wherein the patient is treated for anemia secondary to chemotherapy treatment in cancer.
4. The method of claim 1 wherein said erythropoietin is human recombinant erythropoietin.
5. The method of claim 1 wherein said erythropoietin is Epoietin-α.
6. A method of raising and maintaining the hemoglobin levels in a patient comprising:
a. administering an effective amount of about 5,000 IU/kg of
erythropoietin to a patient by a subcutaneous injection once every week until a hemoglobin increase of about 2 g/dL is achieved; and
b. after achieving the hemoglobin increase of step (a), administering, by subcutaneous injection once every three weeks, an amount that is greater than the amount administered in step (a), such that a hemoglobin level within about 1 g/dL of that achieved in step (a) is maintained.
7. The method of claim 1 , wherein said erythropoietin administered in step (b) is in an amount of 17,000 to 25,000 IU/kg.
8. The method of claim 6 wherein the patient is treated for anemia secondary to chemotherapy treatment in cancer.
9. The method of claim 6 wherein said erythropoietin is human recombinant erythropoietin.
10. The method of claim 6 wherein said erythropoietin is Epoietin-α.