Otic microbial combination for treatment of animals with ruptured tympanic membrane
View Patent ↗Disclosed herein is an improved composition that is useful in treating otic infections comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat otic infections in animals, the improvement comprising the composition which can be used safely to treat animals with a ruptured tympanic membrane.
1. An improved method of treating an otic infection in an animal comprising administering a composition comprising an antimicrobial and silver sulfadiazine in a therapeutically effective combination to treat the otic infection, the improvement comprising administering the composition to an animal with a ruptured tympanic membrane.
2. The method of claim 1 , wherein said composition is administered in a pharmaceutically effective amount.
3. The method of claim 1 , wherein said composition is administered on a twice daily basis.
4. The method of claim 1 , wherein said enrofloxacin is present in an amount from about 0.005 to about 1.5 percent by weight of the composition.
5. The method of claim 4 , wherein said enrofloxacin is present in an amount from about 0.1 to about 1.0 percent by weight of the composition.
6. The method of claim 1 , wherein said silver sulfadiazine is present in an amount from about 0.05 to about 2.0 percent by weight of the composition.
7. The method of claim 6 , wherein said silver sulfadiazine is present in an amount from about 0.5 to about 1.5 percent by weight of the composition.
8. The method of claim 1 , wherein said composition further comprises a physiologically acceptable carrier.
9. The method of claim 8 , wherein said carrier comprises an emulsion.
10. The method of claim 9 , wherein said emulsion comprises and oil in water emulsion.
11. The method of claim 10 , wherein said oil is selected from the group consisting of mineral oil, vegetable oil and reformed vegetable oil.
12. The method of claim 11 , wherein said oil is selected from the group consisting of peanut oil, sesame seed oil, cotton seed oil, and medium chain triglycerides.
13. The method of claim 9 , wherein said emulsion comprises an emulsifier that is present in an amount of about 1.5 to about 6.5 percent by weight of the composition.
14. The method of claim 13 , wherein said emulsifier is selected from the group consisting of sorbitan monostearate and polysorbate 60.
15. The method of claim 9 , wherein said emulsion comprises a non-aqueous phase in an amount of about 15 to about 25 percent by weight of the composition.