IP Library Granted Patent US 7,377,901
Granted Patent B2
US 7,377,901 · App. 10/312,242 · Granted May 27, 2008

Apparatus for collection of airway gases

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Quick Facts
Patent No.
US 7,377,901
App. No.
10/312,242
Granted
May 27, 2008
Kind
B2
Abstract

The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.

Claims (59)

1. An apparatus for collecting airway gases, comprising:

a mouthpiece through which a user in use exhales to deliver a gas flow therethrough, wherein the mouthpiece is configured to provide a resistance to exhalation which is such as to cause closure of the oropharyngeal velum of the user on exhalation therethrough;

a first nosepiece which is fluidly connected to the mouthpiece for fitting to one nostril of the user;

a second nosepiece for fitting to the other nostril of the user;

a collection device which is fluidly connected to the second nosepiece for collecting airway gases as delivered from the second nosepiece; and

a scrubber which is fluidly connected to the mouthpiece for removing one or more gases from the gas flow as delivered to the first nosepiece.

2. An apparatus for collecting airway gases, comprising:

a mouthpiece through which a user in use exhales to deliver a gas flow therethrough, wherein the mouthpiece is configured to provide a resistance to exhalation which is such as to cause closure of the oropharyngeal velum of the user on exhalation therethrough;

a first nosepiece which is fluidly connected to the mouthpiece for fitting to one nostril of the user;

a second nosepiece for fitting to the other nostril of the user;

a collection device which is fluidly connected to the second nosepiece for collecting airway gases as delivered from the second nosepiece; and

a further collection device which is fluidly connected between the mouthpiece and the first nosepiece for collecting one or more gases from the gas flow as delivered to the first nosepiece, wherein the further collection device comprises a condenser.

3. A method of collecting airway gases, comprising the steps of:

a user exhaling through a mouthpiece to deliver a gas flow therethrough, wherein the mouthpiece is configured to provide a resistance to exhalation which is such as to cause closure of the oropharyngeal velum of the user on exhalation therethrough;

fitting a first nosepiece, which is fluidly connected to the mouthpiece, to one nostril of the user;

fitting a second nosepiece to the other nostril of the user; and

collecting airway gases as delivered from the second nosepiece in a collection device which is fluidly connected thereto.

4. The method of claim 3 , wherein the collection device comprises a collection reservoir.

5. The method of claim 3 , wherein the collection device comprises a condenser.

6. The method of claim 3 , further comprising the step of:

removing one or more gases from the gas flow as delivered to the first nosepiece.

7. The method of claim 3 , further comprising the step of:

collecting one or more gases from the gas flow as delivered to the first nosepiece in a further collection device which is fluidly connected between the mouthpiece and the first nosepiece.

8. The method of claim 7 , wherein the further collection device comprises a collection reservoir.

9. The method of claim 7 , wherein the collection device comprises a condenser.

10. The method of claim 3 , further comprising the step of:

collecting one or more substances from the delivered gas flow in at least one collection element.

11. The method of claim 10 , wherein the substance comprises a gas.

12. The method of claim 10 , wherein the substance comprises particles.

13. The method of claim 10 , wherein the substance comprises micro-organisms or parts thereof.

14. The method of claim 10 , wherein any or each collection device includes a collection element.

15. The method of claim 14 , wherein the collection element comprises a coating within the respective collection device.

16. The method of claim 14 , wherein the collection element is a removable element.

17. The method of claim 16 , wherein the collection element is a filter.

18. The method of claim 10 , wherein the at least one collection element is a removable element.

19. The method of claim 18 , wherein the at least one collection element is disposed downstream of the second nosepiece.

20. The method of claim 18 , wherein the at least one collection element is a filter.

21. A method of collecting airway gases, comprising the steps of:

a user exhaling into a mouthpiece, wherein the mouthpiece is configured to provide a resistance to exhalation which is such as to cause closure of the oropharyngeal velum of the user on exhalation thereinto;

fitting a nosepiece to one nostril of a nasal airway of the user;

providing a gas flow through the nasal airway of the user from the other nostril to the one nostril of the user while the oropharyngeal velum of the user is closed; and

collecting airway gases as delivered from the nosepiece in a collection device which is fluidly connected thereto.

22. The method of claim 21 , wherein the collection device comprises a collection reservoir.

23. The method of claim 21 , wherein the collection device comprises a condenser.

24. The method of claim 21 , further comprising the step of:

collecting one or more gases from the exhaled gas flow as delivered to the mouthpiece in a further collection device which is fluidly connected thereto.

25. The method of claim 24 , wherein the further collection device comprises a collection reservoir.

26. The method of claim 24 , wherein the further collection device comprises a condenser.

27. The method of claim 21 , further comprising the step of:

collecting one or more substances from the gas flow in at least one collection element which is disposed downstream of the nosepiece.

28. The method of claim 27 , wherein the substance comprises a gas.

29. The method of claim 27 , wherein the substance comprises particles.

30. The method of claim 27 , wherein the substance comprises micro-organisms or parts thereof.

31. The method of claim 27 , wherein any or each collection device includes a collection element.

32. The method of claim 31 , wherein the collection element comprises a coating within the collection device.

33. The method of claim 31 , wherein the collection element is a removable element.

34. The method of claim 33 , wherein the collection element is a filter.

35. The method of claim 27 , wherein the at least one collection element is a removable element.

36. The method of claim 35 , wherein the at least one collection element is a filter.

Assignments (7)
RELEASE OF SECURITY INTEREST Recorded May 21, 2025
From: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
To: OPTINOSE INC.
Reel/Frame 071547/0979 →
CHANGE OF ADDRESS Recorded Jan 6, 2025
From: OPTINOSE, INC.
To: OPTINOSE, INC.
Reel/Frame 069825/0599 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 27, 2022
From: OPTINOSE AS
To: OPTINOSE INC
Reel/Frame 061546/0424 →
RELEASE OF SECURITY AGREEMENT RECORDED AT REEL 044976 FRAME 0505 Recorded Sep 13, 2019
From: ATHYRIUM OPPORTUNITIES III ACQUISITION LP
To: OPTINOSE AS
Reel/Frame 050371/0894 →
SECURITY INTEREST Recorded Sep 13, 2019
From: OPTINOSE AS
To: BIOPHARMA CREDIT PLC, AS COLLATERAL AGENT
Reel/Frame 050371/0913 →
SECURITY INTEREST Recorded Dec 29, 2017
From: OPTINOSE AS
To: ATHYRIUM OPPORTUNITIES III ACQUISITION LP
Reel/Frame 044976/0505 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2006
From: DJUPESLAND, PER GISLE; QIAN, WEI
To: OPTINOSE AS
Reel/Frame 017389/0662 →