Functionated photoacid generator and functionated polymer system for biological microarray synthesis

1. A method for making polymer arrays comprising:

a) Coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms;

 wherein x and y are repeating units of the structure;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas, wherein the monomer is a nucleotide.

2. A method for making polymer arrays comprising:

a) Coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms;

 wherein x and y are repeating units of the structure;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas; wherein the monomer is an amino acid.

3. A method for making polymer arrays comprising:

a) Coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms;

 wherein x and y are repeating units of the structure, wherein the hydroxyl group is present at either the ortho, meta or para positions throughout the polymer and wherein the R group is substituted by one or more halogen;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas.

4. The method of claim 3 wherein the phenolic units of the polymer is substituted by one or more halogen.

5. A method of making polymer arrays comprising:

a) coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms, and wherein R is substituted by one or more halogens;

 wherein R′ is substituted or unsubstituted alkyl oxycarbonyl located at either the ortho, meta, or para positions; and

 wherein x and y are repeating units of the structure;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas.

6. A method of making polymer arrays comprising:

a) coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms;

 wherein R′ is substituted or unsubstituted alkyl oxycarbonyl located at either the ortho, meta, or para positions and wherein R′ is substituted by one of more halogens; and

 wherein x and y are repeating units of the structure;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas.

7. A method of making polymer arrays comprising:

a) coating a substrate with a reactive polymer matrix and a photo carboxylic acid generator; wherein the reactive polymer has the structure of:

 wherein R is substituted or unsubstituted alkyl having 1 to about 18 carbon atoms;

wherein R′ is substituted or unsubstituted alkyl oxycarbonyl located at either the ortho, meta, or para positions;

 wherein x and y are repeating units of the structure; and

 wherein the phenolic unit of the polymer is substituted by one or more halogen;

b) exposing the substrate with patterned radiation to remove acid labile protecting group in reaction areas;

c) coupling a monomer into the reaction areas.