Cleaning compound for and method of cleaning valves and actuators of metered dose dispensers containing pharmaceutical compositions
A method of cleaning a metered dose spray device, and a cleaning composition for such cleaning, prevent the device from becoming clogged with medication. The method includes removing the aerosol can containing the medication from the actuator, placing an aerosol can containing a cleaning composition in the actuator, and dispensing the cleaning solution through the actuator. The residual medication is thereby removed from the actuator. A sufficiently small quantity of cleaning composition remains in the actuator so that the cleaning composition itself will not clog the actuator. Additionally, the cleaning composition is non-toxic, so that residual cleaning composition remaining in the actuator will not harm the user when a subsequent dose of medication is dispensed.
1. A method of cleaning an actuator of an aerosol metered dose dispenser containing a pharmaceutical product, comprising:
replacing the canister containing the pharmaceutical product with a canister containing a cleaning composition; and
discharging the cleaning canister at least one time after discharge of the pharmaceutical product so that the pharmaceutical product residue present in the actuator is substantially removed by the discharge of the cleaning composition therethrough.
2. The method of claim 1 , wherein said cleaning composition is comprised of a propellant and silicone.
3. The method of claim 2 , wherein said propellant is selected from the group consisting of tetrafluoroethane, heptafluoroethane, dimethylfluoropropane,, tetrafluoropropane, butane, isobutane, diethyl ether, hydrogen-containing chlorofluorocarbons, hydrogen-containing chlorofluorocarbons, hydrogen-containing fluorocarbons, and diethyl ether.
4. The method of claim 2 , wherein the propellant is present in a concentration of about 90 to 99 wt./wt. % of the total cleaning composition and the silicone is present in a concentration of about 1 to 10 wt./wt. % of the total cleaning composition.
5. The method of claim 2 , further comprising an organic solvent.
6. The method of claim 5 , wherein the organic solvent is selected from the group consisting of alcohol solutions and ethanol an alcohol solution.
7. The method of claim 6 , wherein the alcohol solution is ethanol.