Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
View Patent ↗The present invention is directed to medical devices and pharmaceutical or agricultural compositions, and seeds, each containing a synthetic, bioabsorbable, biocompatible polymeric wax that is the reaction product of a polybasic acid or derivative thereof, a polyol and a fatty acid, the polymeric wax having a melting point less than about 70° C., as determined by differential scanning calorimetry, and an effective amount of rapamycin or an analogue thereof.
1. A composition, comprising: an effective amount of rapamycin or an analogue thereof such that said composition functions as an immunosuppresant, and a polymeric wax comprising the reaction product of a polybasic acid or derivative thereof, a fatty acid and a polyol, said polymeric wax comprising an aliphatic polyester backbone having fatty acid ester groups pending therefrom and having a melting point less than about 70° C., as determined by differential scanning calorimetry.
2. The composition of claim 1 wherein said polymeric wax comprises the reaction product of said polybasic acid or derivative thereof and a monoglyceride, said monoglyceride comprising the reaction product of said fatty acid and said polyol.
3. The composition of claim 1 wherein said polybasic acid or derivative thereof is selected from the group consisting of succinic acid, succinic anhydride, malic acid, tartaric acid, citric acid, diglycolic acid, diglycolic anhydride, glutaric acid, glutaric anhydride, adipic acid, pimelic acid, suberic acid and sebacic acid.
4. The composition of claim 2 wherein said monoglyceride is selected from the group consisting of monostearoyl glycerol, monopalmitoyl glycerol, monomyrisitoyl glycerol, monocaproyl glycerol, monodecanoyl, monolauroyl glycerol, monolinoleoyl glycerol and monooleoyl glycerol.
5. The composition of claim 4 wherein said polybasic acid derivative is succinic anhydride.
6. The composition of claim 2 wherein said polymeric wax has a number average molecular weight between about 1,000 g/mole and about 100,000 g/mole, as measured by gel permeation chromatography using polystyrene standards.
7. The composition of claim 2 wherein said polymeric wax is branched.