Stimulation of in vivo production of proteins
View Patent ↗The invention relates to a formulation in the form of a pharmaceutical composition, a food product, a feed product or a dietary supplement, comprising leucine and protein in specific amounts. Consumption of a formulation according to the invention has a very positive effect on the generation of muscle tissue and is therefore particularly useful for organisms wherein an anabolic response is desired.
1. A composition comprising leucine and proteinaceous matter, wherein leucine is present in an amount of at least about 10 wt. % based on a total dry weight of the composition, in a weight ratio of between about 0.2 and 0.4 leucine to other amino acids present in the proteinaceous matter, and in a weight ratio of greater than about 0.48 leucine to a total amount of branched amino acids.
2. The composition of claim 1 , wherein leucine is present in an amount of about 12 to 80 wt. % based on the total dry weight of the composition.
3. The composition of claim 1 , wherein leucine is present in an amount of about 20 to 60 wt. % based on the total dry weight of the composition.
4. The composition of claim 1 , wherein leucine comprises L-leucine.
5. The composition of claim 1 , wherein leucine comprises free leucine.
6. The composition of claim 1 , wherein leucine is present in a weight ratio of between about 0.88 and 20 leucine to a sum of valine and isoleucine.
7. The composition of claim 1 , wherein leucine is present in a weight ratio of between about 1.1 and 10 leucine to a sum of valine and isoleucine.
8. The composition of claim 1 in a daily dosage amount, wherein leucine is present in a weight ratio of between about 0.29 and 0.35 leucine to other amino acids.
9. The composition of claim 1 in a dosage unit, wherein at least about 0.037 grams leucine is present per kilogram bodyweight per dosage unit.
10. The composition of claim 1 in a dosage unit, wherein at least 0.04 grams leucine is present per kilogram bodyweight per dosage unit.
11. The composition of claim 1 , wherein the proteinaceous matter comprises at least about 90 wt. % intact proteins and/or peptides.
12. The composition of claim 1 , wherein the proteinaceous matter is present in an amount such that the composition comprises about 40 to 80 wt. % amino acids, based on the total dry weight of the composition.
13. The composition of claim 1 , wherein the proteinaceous matter is present in such an amount such that the composition comprises about 60 to 75 wt. % amino acids, based on the total dry weight of the composition.
14. The composition of claim 1 further comprising at least about 5 grams of essential amino acids.
15. The composition of claim 14 comprising synthetic L-lysine and/or synthetic L-methionine.
16. The composition of claim 1 further comprising one or more vitamins selected from the group consisting of folic acid, vitamin B6, vitamin B 1, vitamin B2, biotin, lipoic acid, and vitamin B12.
17. The composition of claim 1 further comprising mono- and disaccharides, wherein the mono- and disaccharides are present in an amount of less than about 20 wt. %, based on the total dry weight of the composition.
18. The composition of claim 1 further comprising mono- and disaccharides, wherein the mono- and disaccharides are present in an amount of less than about 10 wt. %, based on the total dry weight of the composition.
19. The composition of claim 1 further comprising mono- and disaccharides, wherein the mono- and disaccharides are present in an amount of less than about 5 wt. %, based on the total dry weight of the composition.
20. The composition of claim 1 , wherein the composition is in a form selected from the group consisting of a pharmaceutical composition, a food product, and a dietary supplement.
21. A food bar comprising:
the composition of claim 1 present in an amount of about 20-40 wt. % of the food bar;
a carbohydrate present in an amount of about 20-40 wt. % of the food bar; and
a lipid present in an amount of about 2-10 wt. % of the food bar.
22. The food bar of claim 21 further comprising conventional food bar ingredients.
23. A composition comprising leucine and proteinaceous matter, wherein leucine is present in an amount of at least about 10 wt. % based on a total dry weight of the composition, wherein leucine is present in a weight ratio of between about 0.2 and 0.4 leucine to other amino acids present in the proteinaceous matter, wherein the leucine is present in a weight ratio of greater than about 0.48 leucine to a total amount of branched amino acids, and wherein a total amount of amino acids and peptides is 50% or less than the total amount of the proteinaceous matter.
24. A composition comprising leucine and proteinaceous matter, wherein leucine is present in an amount of at least about 10 wt. % based on a total dry weight of the composition, wherein leucine is present in a weight ratio of between about 0.2 and 0.4 leucine to other amino acids present in the proteinaceous matter, wherein the leucine is present in a weight ratio of greater than about 0.48 leucine to a total amount of branched amino acids, and wherein a total amount of amino acids and peptides is 30% or less than the total amount of the proteinaceous matter.