End-capped polymers and compositions containing such compounds
View Patent ↗End-capped polymers, methods for making those end-capped polymers and compositions containing those end-capped polymers are disclosed. One of the disclosed end-capped copolymers has the formula: and may be combined with demineralized bone particles to form a tissue repair composition.
1. A polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer wherein both terminal hydroxyl groups in the triblock copolymer have been replaced with terminal methoxy groups and wherein the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer
is derived from a dilithium salt of a dihydroxy starting material, and wherein both of the terminal hydroxyl groups have been replaced with terminal methoxy groups as a result of chemical modification.
2. The compound of claim 1 , wherein the degree of polymerization of both polyoxyethylene blocks is about 101 and the degree of polymerization of the polyoxypropylene block is about 56.
3. A method of making polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer wherein both terminal hydroxyl groups in the triblock copolymer have been replaced with terminal methoxy groups and wherein the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer has no hydroxyl groups comprising:
(a) providing a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer with two terminal hydroxyl groups
(b) contacting the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer defined in step (a) with butyllithium or lithium aluminum hydride to form a dilithium salt and
(c) contacting the product of step (b) with methyl iodide, resulting in complete conversion of all hydroxyl groups in the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer of step (a) into methyl ethers.
4. The method of claim 3 , wherein the degree of polymerization of both polyoxyethylene blocks is about 101 and the degree of polymerization of the polyoxypropylene block is about 56.
5. A composition comprising:
(i) demineralized bone particles, and
(ii) a polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer wherein both terminal hydroxyl groups in the triblock copolymer have been replaced with terminal methoxy groups and wherein the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer wherein the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer
derived from a dilithium salt of a dihydroxy starting material and wherein all of the dihydroxy starting material is completely etherified as a result of chemical modification.
6. The composition according to claim 5 , wherein the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer defined in part (ii) is dispersed in water.
7. The composition according to claim 6 , wherein the dispersion of the polyoxyethylene-polyoxypropylene-polyoxyethylene triblock copolymer defined in part (ii) in water exhibits reverse phase behavior.
8. The composition according to claim 5 , wherein the composition is a tissue repair composition.
9. The composition according to claim 5 , wherein the composition further comprises collagen, gelatin, BMIPs, bone mineral, hydroxyapatite, tricalcium phosphate, biphasic calcium phosphate, calcium sulfate, biological glasses, a natural polymer or a synthetic polymers.