Arylpiperidinopropanol and arylpiprazinopropanol derivatives and pharmaceuticals containing the same
View Patent ↗A compound having the formula (I) or its salt, hydrate, hydrate salt or solvate: wherein R 1 to R 4 independently represent H, halogen, OH, alkoxy, optionally substituted alkyl, aryl, or aralkyl group, R 5 represents H, optionally substituted alkyl, aryl, or aralkyl group, E 1 represents O, S, or —NR 6 , where R 6 represents H, an optionally substituted alkyl, aryl, or aralkyl group, E 2 represents O, S, or —NR 7 , where R 7 represents H, an optionally substituted alkyl, aryl, or aralkyl group, A represents CH, C(OH), or N, X represents H, halogen, alkoxy, or an optionally substituted alkyl group, and Q represents an optionally substituted phenyl group, phenoxy, phenylmethyl, or cycloalkyloxy group, where when E 1 represents O or S, E 2 does not represent O or S, which has an action of suppressing the cytotoxic Ca 2+ overload and lipid peroxidation and effective for pharmaceutical preparation for the alleviation and treatment of symptoms due to ischemic diseases, etc.
1. A compound having the formula (I) or its salt, hydrate, or hydrate salt:
wherein R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom,
R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom,
E 1 represents an oxygen atom, a sulfur atom, or a group —NR 6 , where, R 6 represents a hydrogen atom, an alkyl group or an alkyl group substituted with a halogen atom,
E 2 represents an oxygen atom, a sulfur atom, or a group —NR 7 , wherein R 7 represents a hydrogen atom, an alkyl group or an alkyl group substituted with a halogen atom,
A represents CH or C(OH),
X represents a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, and
Q represents
a phenyl group,
a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a phenoxy group,
a phenoxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a phenylmethyl group,
a phenylmethyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a cycloalkyloxy group, or
a cycoalkyloxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom; and,
wherein, when E 1 represents an oxygen atom or sulfur atom, E 2 does not represent an oxygen atom or a sulfur atom.
2. A compound or its salt, hydrate or hydrate salt as claimed in claim 1 , wherein, in the formula (I), R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom, E 5 represents NH, and E 2 represents an oxygen atom.
3. A compound or its salt, hydrate or hydrate salt as claimed in claim 1 , wherein, in the formula (I), R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom, E 1 represents an oxygen atom, and E 2 represents NH.
4. A compound or its salt, hydrate or hydrate salt as claimed in claim 1 , wherein, in the formula (I), one of R 1 to R 4 is a hydrogen atom and the others each independently represent a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom.
5. A compound or its salt, hydrate or hydrate salt as claimed in claim 1 , wherein the formula (I), Q represents a phenoxy group, a phenoxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group, a C 1 to C 5 linear and branched alkyl group optionally substituted with a halogen atom, a phenylmethyl group, or a phenylmethyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group optionally substituted with a halogen atom.
6. A pharmaceutical composition containing, as an effective ingredient, a compound having the formula (I) or its pharmaceutically acceptable salt, hydrate or hydrate salt:
wherein R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom,
R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom,
E 1 represents an oxygen atom, a sulfur atom, or a group —NR 6 , where, R 6 represents a hydrogen atom, an alkyl group or an alkyl group substitute with a halogen atom,
E 2 represents an oxygen atom, a sulfur atom, or a group —NR 7 , where R 7 represents a hydrogen atom, an alkyl group or an alkyl group substituted with a halogen atom,
A represents CH or C(OH),
X represents a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, and
Q represents
a phenyl group,
a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a phenoxy group,
a phenoxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a phenylmethyl group,
a phenylmethyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a cycloalkyloxy group, or
a cycoalkyloxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom; and,
wherein, when E 1 represents an oxygen atom or sulfur atom, E 2 does not represent an oxygen atom or a sulfur atom.
7. A pharmaceutical composition as claimed in claim 6 , wherein, in the formula (I), R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom, E 1 represents NH, and E 2 represents an oxygen atom.
8. A pharmaceutical composition as claimed in claim 6 , wherein, in the formula (I), R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom, E 1 represents an oxygen atom, and E 2 represents NH.
9. A pharmaceutical composition a claimed in claim 6 , wherein, in the formula (I), one of R 1 to R 4 is a hydrogen atom and the others each independently represent a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom.
10. A pharmaceutical composition as claimed in claim 6 , wherein, in the formula (I), Q represents a phenoxy group, a phenoxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group, a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom, a phenylmethyl group, or a phenylmethyl group substitute with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group, a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom.
11. A process for producing a compound having the formula (I):
wherein R 1 to R 4 each independently represent a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom,
R 5 represents a hydrogen atom, an alkyl group, or an alkyl group substituted with a halogen atom,
E 1 represents an oxygen atom, a sulfur atom, or a group —NR 6 , where, R 6 represents a hydrogen atom, an alkyl group or an alkyl group substituted with a halogen atom,
E 2 represents an oxygen atom, a sulfur atom, or a group —NR 7 , where R 7 represents a hydrogen atom, an alkyl group or an alkyl group substituted with a halogen atom,
A represents CH or C(OH),
X represents a hydrogen atom, a halogen atom, an alkoxy group, an alkyl group, or an alkyl group substituted with a halogen atom, and
Q represents
a phenyl group,
a phenyl group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a Cto C 5 linear or branched alkyl group substituted with a halogen atom,
a phenoxy group,
a phenoxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a phenylmethyl group,
a phenylmethyl group substituted with a substituent select from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom,
a cycloalkyloxy group, or
a cycoalkyloxy group substituted with a substituent selected from the group consisting of a halogen atom, a hydroxy group, a C 1 to C 5 linear or branched alkoxy group, a C 1 to C 5 linear or branched alkyl group and a C 1 to C 5 linear or branched alkyl group substituted with a halogen atom, and
wherein, when E 1 represents an oxygen atom or sulfur atom, E 2 does not represent an oxygen atom or a sulfur atom,
which process comprises reacting a compound having the formula (IV):
wherein X and Q are the same as defined above, or a compound having the formula (X):
wherein X and Q are the same as defined above,
with a compound having the formula (VIIa):
wherein R 1 to R 4 , E 1 and E 2 are the same as defined above and R 8 represents an alkyl group, an alkyl group substituted with a halogen atom, a benzyl group, a p-methoxybenzyl group, a benzyloxycarbonyl group, a p-methoxybenzyloxycarbonyl group, a p-nitrobenzyloxycarbonyl group, a tert-butoxycarbonyl group, an ethoxycarbonyl group, an acetyl group or a formyl group, or a compound having the formula (VIIb):
wherein R 1 to R 4 , R 8 , E 1 and E 2 are the same as defined above, L represents a group which can be easily exchanged with an amino group, or a compound having the formula (VIIc):
wherein R 1 to R 4 , R 8 , E 1 and E 2 are the same as defined above, and deprotecting the compound obtained by the above reaction, having the formula (VIII′):
wherein R 1 to R 4 , R 8 , E 1 , E 2 , A, X and Q are the same as defined above, to give products having the above formula (I).
12. A method for alleviating or treating symptoms due to ischemic diseases, comprising administering to a patient in need of such alleviation or treatment an effective amount of a pharmaceutical composition of claim 6 .
13. A method as claimed in claim 12 , wherein said pharmaceutical composition is orally or non-orally administered.
14. A method for alleviating or treating symptoms derived from seizures or epilepsy comprising administering to a patient in need of such alleviation or treatment an effective amount of a pharmaceutical composition of claim 6 .