Remedies for cancer
View Patent ↗A medicament for treating cancer for use in combination therapy with an anti-HER2 antibody, which comprises amrubicin or a pharmaceutically acceptable salt thereof as an active ingredient.
1. A method of treating breast cancer, which is a breast cancer in which HER2 is highly expressed, comprising administering an effective amount of trastuzumab and an effective amount of amrubicin or a pharmaceutically acceptable salt thereof in combination, whereby said breast cancer is treated.
2. The method according to claim 1 , comprising administering amrubicin or a pharmaceutically acceptable salt thereof at 0.5–3.0 mg/kg/day while administering trastuzumab at 0.1–4.5 mg/kg/day.
3. The method according to claim 2 , comprising administering amrubicin or a pharmaceutically acceptable salt thereof on successive three days in every three weeks, while administering trastuzumab every one week.
4. The method according to claim 1 , comprising administering amrubicin or a pharmaceutically acceptable salt thereof at 1.5–9.0 mg/kg/day while administering trastuzumab at 0.1–4.5 mg/kg/day.
5. The method according to claim 4 , comprising administering amrubicin or a pharmaceutically acceptable salt thereof every three weeks, while administering trastuzumab every one week.
6. The method according to any one of claims 1 and 2 to 5 , wherein a dosage ratio of amrubicin or a pharmaceutically acceptable salt thereof and trastuzumab is 2:1–8:1 at one week after initiating the administration of both agents.