Hemostatic compositions and methods for controlling bleeding
View Patent ↗The invention provides hemostatic compositions useful to promote hemostasis at active bleeding wound sites. The hemostatic compositions typically include an article containing cellulose, e.g., cotton gauze, and a polysaccharide covalently linked to the cellulose, or a polysaccharide ionically cross-linked and in association with the article. Methods of making and using the hemostatic compositions are also provided.
1. A bandage consisting essentially of a hemostatic composition, said hemostatic composition comprising cellulose and dextran covalently linked to said cellulose.
2. The bandage of claim 1 , wherein said dextran is in the form of covalently cross-linked beads.
3. The bandage of claim 1 , wherein the molecular weight of said dextran ranges from about 10,000 to about 2,000,000 Daltons.
4. The bandage of claim 3 , wherein the molecular weight of said dextran ranges from about 20,000 to about 100,000 Daltons.
5. The bandage of claim 1 , wherein said covalently linked dextran has a molecular weight exclusion limit greater than about 30,000 Daltons.
6. The bandage of claim 1 , wherein said cellulose is cotton.
7. The bandage of claim 6 , wherein said cellulose is cotton gauze.
8. The bandage of claim 1 , further comprising cross-linked alginate linked to said cellulose.
9. The bandage of claim 8 , wherein said cross-linked alginate is covalently linked to said cellulose.
10. The bandage of claim 8 , wherein said dextran is in the form of covalently cross-linked beads.
11. The bandage of claim 10 , wherein said covalently cross-linked dextran beads comprise Ca2+.
12. A bandage comprising a hemostatic composition, said hemostatic composition comprising ionically linked dextran-alginate spheres covalently linked to cellulose.
13. The bandage of claim 12 , wherein said ionically linked dextran-alginate spheres are linked ionically with Ca2+.
14. The bandage of claim 13 , wherein said ionically linked dextran-alginate spheres are further cross-linked covalently.