Method and apparatus for penetrating tissue
View Patent ↗A skin penetrating system includes a housing member and a penetrating member positioned in the housing member. An analyte detecting member is coupled to a sample chamber. The analyte detecting member is configured to determine a concentration of an analyte in a body fluid using a sample of less than 1 μL of a body fluid disposed in the sample chamber. A tip of the penetrating member is configured to extend through an opening of the sample chamber.
1. A skin penetrating system, comprising:
a housing member;
an electronic drive force generator;
a plurality of penetrating members positioned in the housing member, each of a penetrating member being couplable to the drive force generator;
a plurality of sample chambers, each sample chamber including electrodes, having a volume no greater than 1 μL and an analyte sensor, each of a sample chamber being positioned to receive fluid from a wound created by a penetrating member, and determine a concentration of an analyte in a fluid using a sample of less than 1 μL of the fluid, wherein when the penetrating member is removed from the sample chamber, the electrodes remain in the sample chamber and the volume of the sample chamber is less than 1 μL wherein a tip of the penetrating member is configured to extend through an opening of a sample chamber, wherein each penetrating member of the plurality of penetrating members has a packing density of no more than 1.0 cm 3 /penetrating member;
a single substrate that supports the plurality of penetrating members and the plurality of sample chambers, the single substrate being rotatably positioned in the housing to position each of a penetrating member in a launch position to penetrate a tissue site, and then rotate to a next position for a launch position of a next penetrating member; and
a programmable processor operatively programmed with software that has control instructions for controlling the drive force generator, to keep a wound tract created by a penetrating member open for a sufficient time to provide for spontaneous flow of blood for sample capture into an associated sample chamber, the control instructions selected from at least one of, penetration depth of a penetrating member, velocity of a penetrating member, velocity of a penetrating member in or out of target tissue and a dwell time of a penetrating member in the target tissue.
2. The system of claim 1 , further comprising:
a penetrating member sensor coupled to the processor and the plurality of penetrating members, the penetrating member sensor configured to provide information relative to a depth of penetration of a penetrating member through a skin surface.
3. The system of claim 1 , further comprising:
a plurality of cartridges positioned in a disposable member, each of a cartridge including a penetrating member and a sample chamber, the plurality of cartridges positioned on the single substrate.
4. The system of claim 3 , wherein each of a cartridge has an exit port, and upon launch each of an associated penetrating member exits from the exit port.
5. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members has a packing density of no more than 0.75 cm 3 /penetrating member.
6. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members has a packing density of no more than 0.5 cm 3 /penetrating member.
7. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members has a packing density of no more than 0.25 cm 3 /penetrating member.
8. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members has a packing density of no more than 0.1 cm 3 /penetrating member.
9. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members and each associated sample chamber of the plurality of sample chambers have a combined packing density of no more than 1.0 cm 3 .
10. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members and each associated sample chamber of the plurality of sample chambers have a combined packing density of no more than 0.75 cm 3 .
11. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members and each associated sample chamber of the plurality of sample chambers have a combined packing density of no more than 0.5 cm 3 .
12. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members and each associated sample chamber of the plurality of sample chambers have a combined packing density of no more than 0.25 cm 3 .
13. The system of claim 1 , wherein each penetrating member of the plurality of penetrating members and each associated sample chamber of the plurality of sample chambers have a combined packing density of no more than 0.1 cm 3 .
14. The system of claim 1 , wherein each penetrating member is an elongated member without molded attachments.