Method for purifying 2-chloro-5-chloromethylthiazole
View Patent ↗The present invention relates to a process for the preparation of pure 2-chloro-5 -chloromethylthiazole by distillation in the presence of oligomeric polyethers.
1. A process for purifying 2-chloro-5-chloromethyl-thiazole comprising distilling crude 2-chloro-5-chloromethylthiazole under reduced pressure in the presence of an oligomeric polyether.
2. A process according to claim 1 wherein the polyether is polyethylene glycol or polypropylene glycol.
3. A process according to claim 2 wherein the polyether has an average molar mass between 200 and 3000 daltons.
4. A process according to claim 2 wherein the polyether has an average molar mass between 300 and 600 daltons.
5. A process according to claim 2 wherein the polyether has an average molar mass of 400 daltons.
6. A process according to claim 1 wherein the polyether has an average molar mass between 200 and 3000 daltons.
7. A process according to claim 1 wherein the polyether has an average molar mass between 300 and 600 daltons.
8. A process according to claim 1 wherein the polyether has an average molar mass of 400 daltons.
9. A process according to claim 1 wherein the distillation is carried out at a pressure between 0.5 mbar and 10 mbar.
10. A process according to claim 1 wherein the distillation is carried out at a pressure between 1 mbar and 4 mbar.
11. A process according to claim 1 wherein the distillation is carried out at a temperature between 60 and 150° C.
12. A process according to claim 1 wherein the distillation is carried out at a bottom temperature between 70 and 120° C.
13. A process according to claim 1 wherein the amount of the polyether is between 0.01 and 10 times the weight-by-weight amount of a diluent-free crude 2-chloro-5-chloromethylthiazole.
14. A process according to claim 1 wherein the amount of the polyether is between 0.1 and 4 times the weight-by-weight amount of a diluent-free crude 2-chloro-5-chloromethylthiazole.