IP Library › Granted Patent US 7,041,646
Granted Patent B2
US 7,041,646 · App. 10/345,751 · Granted May 9, 2006

Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists

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Quick Facts
Patent No.
US 7,041,646
App. No.
10/345,751
Granted
May 9, 2006
Kind
B2
Abstract

The invention provides polypeptides that act both as an agonist of the GLP-1 receptor and an antagonist of the glucagon receptor. Such polypeptides are useful for treating individuals with type 2 diabetes or other metabolic disorders.

Claims (3)

1. A method of treating type 2 diabetes comprising administering to a mammal an effective amount of a peptide consisting of the amino acid sequence selected from the group consisting of SEQ ID NOs: 6 through 32.

2. The method of claim 1 , wherein the peptide is selected from the group consisting of SEQ ID NO:25, SEQ ID NO:26, and SEQ ID NO:27.

3. The method of claim 1 , further comprising administering, metformin in combination with said peptide.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2009
From: BAYER PHARMACEUTICALS CORPORATION
To: BAYER HEALTHCARE LLC
Reel/Frame 023027/0804 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2003
From: PAN, CLARK; WHELAN, JAMES; CLAIRMONT, KEVIN B.
To: BAYER PHARMACEUTICALS CORPORATION
Reel/Frame 013724/0591 →