IP Library › Granted Patent US 6,943,172
Granted Patent B2
US 6,943,172 · App. 10/349,176 · Granted Sep 13, 2005

Rho-kinase inhibitors

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Quick Facts
Patent No.
US 6,943,172
App. No.
10/349,176
Granted
Sep 13, 2005
Kind
B2
Abstract

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.

Claims (5)

1. A compound of the formula

2. A method of treating an indication mediated by Rho-kinase, comprising administering a compound of claim 1 .

3. A process according to claim 1 , wherein the host is a human.

4. A method of treating hypertension, atherosclerosis, restenosis, cerebral ischemia, cerebral vasospasm, neuronal degeneration, spinal cord injury, cancer of the breast, colon, prostate, ovaries, brain or lung, thrombotic disorders, asthma, glaucoma, osteoporosis or erectile dysfunction, comprising administering to host in need thereof a compound according to claim 1 .

5. A process according to claim 4 , wherein the host is a human.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 27, 2009
From: BAYER PHARMACEUTICALS CORPORATION
To: BAYER HEALTHCARE LLC
Reel/Frame 023027/0804 →