IP Library Granted Patent US 6,918,922
Granted Patent B2
US 6,918,922 · App. 10/353,130 · Granted Jul 19, 2005

Ischemia laser treatment

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Quick Facts
Patent No.
US 6,918,922
App. No.
10/353,130
Granted
Jul 19, 2005
Kind
B2
Abstract

Apparatus for treatment of an ischemic region of brain cells in a cranium, comprising a skull covering adapted to cover at least part of the cranium, at least one guide attached to the skull covering, and a laser source which is operative to direct a laser beam through the at least one guide into the cranium. The at least one guide may include an optic filiter or a waveguide.

Claims (38)

1. A therapy apparatus for treating brain tissue, the therapy apparatus comprising:

a skull covering adapted to cover at least a portion of a patient's cranium;

said skull covering including at least one light source; and

a controller operatively connected to the light source and controlling operation of the light source;

wherein said at least one light source is positioned to irradiate a portion of a patient's cranium with light having a wavelength and power density sufficient to:

penetrate the patient's skull; and

deliver an efficacious amount of light to brain tissue to treat brain cells following ischemic stroke in a patient thereby producing a cytoprotective effect and an increase in survival of neurons.

2. The apparatus of claim 1 , wherein the light source is a laser source.

3. The apparatus of claim 1 , wherein the light source is moveable with respect to the cranium.

4. The apparatus of claim 1 , further comprising an actuator operative to move the light source further from or closer to the cranium.

5. The apparatus of claim 1 , wherein the light source is attached to a plurality of guides such that light from the source passes through the guides.

6. The apparatus of claim 1 , wherein the light source has a wavelength of about 807 nm.

7. The apparatus of claim 1 , wherein the light source delivers a power density of about 8 mW/cm 2 to brain tissue.

8. The apparatus of claim 1 , wherein the apparatus comprises two or more light sources.

9. Apparatus for treatment of an ischemic region of brain cells in a cranium, comprising:

a skull covering adapted to cover at least part of a cranium;

at least one guide attached to said skull covering;

a laser source operative to direct a laser beam through said at least one guide into a cranium; and

a controller operatively connected to the laser source and controlling operation of the laser source;

wherein said light source produces light having a wavelength and power density sufficient to:

penetrate the patient's skull; and

deliver an efficacious amount of light to brain tissue to cause biostimulation of brain cells following ischemic stroke.

10. The apparatus according to claim 9 wherein said at least one guide comprises an optic fiber.

11. The apparatus according to claim 9 wherein said at least one guide comprises a waveguide.

12. The apparatus according to claim 9 comprising a plurality of said guides attached to said skull covering which direct a plurality of laser beams in a plurality of directions.

13. The apparatus according to claim 9 comprising a plurality of said guides attached to said skull covering which focus a plurality of laser beams in a plurality of focal lengths into a cranium.

14. The apparatus according to claim 9 comprising a plurality of said guides which are commonly attached to said laser source.

15. The apparatus according to claim 9 comprising a plurality of said laser sources and a plurality of said guides, wherein each source directs a laser beam through one said guide.

16. A method of treating brain tissue, the method comprising:

identifying a patient whose brain has at least one ischemic portion; and

irradiating at least a portion of the cranium of said patient with light;

wherein said irradiating is performed through the skull

wherein said light has a wavelength and power density sufficient to penetrate the skull; and

cause biostimulation of brain cells and increased neuron survival following an ischemic event.

17. The method according to claim 16 , wherein the wavelength is about 807 nm.

18. The method according to claim 16 , wherein the power density is selected to provide a power density of about 5 mW/cm 2 to about 8 mW/cm 2 to the brain tissue.

19. The method according to claim 16 , wherein the light has a protective effect on the brain cells.

20. The method according to claim 16 , wherein the light causes a regeneration process in the injured brain cells.

Assignments (6)
TERMINATION OF PATENT SECURITY AGREEMENT Recorded May 22, 2009
From: WARBURG PINCUS PRIVATE EQUITY IX, L.P.
To: PHOTOTHERA, INC.
Reel/Frame 022722/0784 →
RELEASE OF SECURITY INTEREST Recorded May 13, 2009
From: LIGHTHOUSE CAPITAL PARTNERS VI, L.P.
To: PHOTOTHERA, INC.
Reel/Frame 022678/0273 →
SECURITY AGREEMENT Recorded Sep 3, 2008
From: PHOTOTHERA, INC.
To: WARBURG PINCUS PRIVATE EQUITY IX, L.P.
Reel/Frame 021462/0922 →
SECURITY AGREEMENT Recorded Aug 29, 2008
From: PHOTOTHERA, INC.
To: LIGHTHOUSE CAPITAL PARTNERS VI, L.P.
Reel/Frame 021462/0135 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2007
From: ORON, AMIR
To: ORON,URI
Reel/Frame 018989/0227 →
LICENSE AGREEMENT INCLUDING ASSIGNMENT Recorded Mar 7, 2007
From: ORON,URI
To: PHOTOTHERA, INC.
Reel/Frame 018989/0232 →