Ion exchange materials for use in a
View Patent ↗A bismuth-213 generator comprising an insoluble composition having the general formula Zr(Phosponate) x (HPO 4 ) 2−x .nH 2 O, wherein x is between 0 and 2; and n is the number of waters of hydration; and wherein cations of radioactive isotopes selected from radium, actinium and combinations thereof are immobilized on the composition. The value of x may be between about 0.2 and about 1. The phosphonate may be n-phosphonomethyl-miniodiacetic acid (PMIDA), wherein x may be between about 0.1 and about 1.9. The phosphonate may be one or more phosphonate having the formula: H 2 O 3 P—(CH 2 ) a —N—((CH 2 ) b CO 2 H)—((CH 2 ) c CO 2 H), wherein a, b, and c are numbers from 1 to 3 that may or may not be equal. The value of x may also be between about 0.1 and 1.9.
1. A radioactive isotope generator, comprising:
an elutable container defining an eluant flow path through a fluid permeable matrix comprising a substantially non-elutable and insoluble composition having the general formula:
Zr(Phosphonate) x (HPO 4 ) 2−x *nH 2 O
wherein: x is between 0 and 2, and n is the number of waters of hydration; and
wherein cations of one or more radioactive parent isotopes are immobilized on the composition.
2. The generator of claim 1 wherein the one or more radioactive parent isotopes are selected from radium, actinium and combinations thereof.
3. The generator of claim 1 , wherein x is between 0.2 and 1.
4. The generator of claim 1 , wherein the phosphonate is n-phosphonomethyl-miniodiacetic acid (PMIDA, N(CH 2 CO 2 H) 2 (CH 2 PO 3 H 2 ).
5. The generator of claim 4 , wherein x is between 0.1 and 1.9.
6. The generator of claim 1 , wherein the phosphonate is one or more phosphonate having the formula:
H 2 O 3 P—(CH 2 ) a —N—((CH 2 ) b CO 2 H)—((CH 2 ) c CO 2 H)
wherein: a, b, and c are numbers from 1 to 3 that may or may not be equal.
7. The generator of claim 1 , wherein x is between 0.1 and 1.9.
8. The generator of claim 1 , wherein x is between 0.2 and 1.
9. A radioactive isotope generator comprising an elutable container defining an eluant flow path, the container containing a matrix comprising a substantially non-elutable inorganic layered zirconium compound containing a mixture of phosphate and phosphonate ligands, the compound containing a parent radioactive isotope.
10. The generator of claim 9 , wherein the ratio of phosphate to phosphonate is between 0.1 and 10.
11. The generator of claim 9 , wherein the phosphonate is n-phosphonomethyl-miniodiacetic acid (PMIDA).
12. The generator of claim 9 , wherein the phosphonate is one or more phosphonate having the formula:
H 2 O 3 P—(CH 2 ) a —N—((CH 2 ) b CO 2 H)—((CH 2 ) c CO 2 H)
wherein: a, b, and care numbers from 1 to 3 that may or may not be equal.
13. The generator of claim 9 , wherein the radioactive isotope is produced by the decay of the parent radioactive isotope.
14. A radionuclide generator comprising an elutable container defining an eluant flow path, the container containing an insoluble inorganic layered phosphate or phosphonate matrix including a compound containing actinium-225, the matrix being permeable to fluid passage and permitting diffusion of a daughter isotope through the matrix.
15. The generator of claim 14 , wherein the matrix is prepared by reacting a mixture of phosphoric acid and a substituted phosphoric or phosphonic acid with a source of zirconium.
16. The composition of claim 14 , wherein the source of zirconium is soluble.
17. The composition of claim 14 , wherein the source of zirconium is ZrOCl 2 .
18. A method comprising:
immobilizing cations of a radioactive parent isotope onto an insoluble matrix of a cation exchange composition selected from zirconium phosphate, zirconium phosphonate, or combinations thereof; and
eluting daughter isotopes from the insoluble composition with an aqueous solution.
19. The method of claim 18 , wherein the aqueous solution comprises a complexing agent.
20. The method of claim 19 , wherein the complexing agent is ethylenediaminetetraacetic acid.
21. The method of claim 19 , wherein the complexing agent is selected from ethylenediaminetetraacetic acid, nitrilotriacetic acid, citric acid, hydroxyethyl ethylenediaminetriacetic acid, and combinations thereof.
22. The method of claim 19 , wherein the aqueous solution has a neutral pH.
23. The method of claim 19 , wherein the aqueous solution comprises a salt of a weak acid.
24. The method of claim 18 , wherein the composition is characterized by an actinium/bismuth separation factor greater than 100.
25. The method of claim 18 , wherein the composition is characterized by an actinium/bismuth separation factor greater than 1,000.
26. The method of claim 18 , wherein the composition is characterized by an actinium/bismuth separation factor greater than 2,000.
27. The method of claim 18 , wherein the composition is characterized by an actinium/bismuth separation factor greater than 3,000.
28. The method of claim 18 , wherein the bismuth-213 is produced from the decay of actinium-225.