Compounds and compositions for delivering active agents

1. A compound selected from the group consisting of compounds:

and salts thereof.

2. A composition comprising:

(A) a biologically active agent; and

(B) at least one compound of claim 1 .

3. The composition of claim 2 , wherein the biologically active agent comprises at least one protein, polypeptide, peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.

4. The composition of claim 2 , wherein the biologically active agent is selected from the group consisting of: growth hormones, human growth hormones recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, growth hormone releasing hormones, growth hormone releasing factor, interferons, α-interferon, β-interferon, γ-interferon, interleukin-1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor (IGF), IGF-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin, eel calcitonin, human calcitonin; erythropoietin (EPO), atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing-hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoietin, filgrastim, postaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine (DFO), parathyroid hormone (PTH), fragments of PTH, antimicrobials, anti-fungal agents, vitamins; analogs, fragments, mimetics and polyethylene glycol (PEG)-modified derivatives of these compounds; and any combination thereof.

5. The composition of claim 2 , wherein the biologically active agent comprises insulin, heparin, calcitonin, parathyroid hormone, erythropoietin, human growth hormone, or combinations thereof.

6. The composition of claim 2 , wherein the biologically active agent comprises recombinant human growth hormones.

7. The composition of claim 2 , wherein the biologically active agent comprises parathyroid hormone.

8. The composition of claim 2 , wherein the biologically active agent comprises insulin.

9. The composition of claim 2 , wherein the biologically active agent comprises heparin.

10. The composition of claim 2 , wherein the biologically active agent comprises calcitonin.

11. The composition of claim 2 , wherein the biologically active agent comprises interferon.

12. A dosage unit form comprising:

(A) the composition of claim 2 ; and

(B) (a) an excipient

(b) a dilutent

(c) a disintegrant,

(d) a lubricant,

(e) a plasticizer,

(f) a colorant,

(g) a dosing vehicle, or

(h) any combination thereof.

13. The dosage unit form of claim 12 , wherein the biologically active agent comprises at least one protein, polypeptide, peptide, hormone, polysaccharide, mucopolysaccharide, carbohydrate, or lipid.

14. The dosage unit form of claim 12 , wherein the biologically active agent is selected from the group consisting of:

growth hormones, human growth hormones (hGH), recombinant human growth hormones (rhGH), bovine growth hormones, porcine growth hormones, growth hormone releasing hormones, growth hormone releasing factor, interferons, α-interferon, β-interferon, γ-interferon, interleukin- 1, interleukin-2, insulin, porcine insulin, bovine insulin, human insulin, human recombinant insulin, insulin-like growth factor, insulin-like growth factor-1, heparin, unfractionated heparin, heparinoids, dermatans, chondroitins, low molecular weight heparin, very low molecular weight heparin, ultra low molecular weight heparin, calcitonin, salmon calcitonin, eel calcitonin, human calcitonin; erythropoietin, atrial naturetic factor, antigens, monoclonal antibodies, somatostatin, protease inhibitors, adrenocorticotropin, gonadotropin releasing hormone, oxytocin, leutinizing-hormone-releasing-hormone, follicle stimulating hormone, glucocerebrosidase, thrombopoeitin, filgrastim, postaglandins, cyclosporin, vasopressin, cromolyn sodium, sodium chromoglycate, disodium chromoglycate, vancomycin, desferrioxamine, parathyroid hormone, fragments of PTH, antimicrobials, anti-fungal agents, vitamins; analogs, fragments, mimetics and polyethylene glycol-modified derivatives of these compounds; and any combination thereof.

15. The dosage unit form of claim 12 , wherein the biologically active agent comprises insulin, heparin, calcitonin, parathyroid hormone, erythropoietin, human growth hormone, or combinations thereof.

16. The dosage unit form of claim 12 , wherein the biologically active agent comprises recombinant human growth hormone.

17. The dosage unit form of claim 12 , wherein the biologically active agent comprises parathyroid hormone.

18. The dosage unit form of claim 12 , wherein the biologically active agent comprises insulin.

19. The dosage unit form of claim 12 , wherein the biologically active agent comprises heparin.

20. The dosage unit form of claim 12 , wherein the biologically active agent comprises calcitonin.

21. The dosage unit form of claim 12 , wherein the biologically active agent comprises interferon.

22. The dosage unit form of claim 12 , wherein the dosage unit form comprises a dosing vehicle comprising a tablet, a capsule, a powder, or a liquid.

23. The dosage unit form of claim 12 , wherein the dosing vehicle is a liquid selected from the group consisting or water, 1,2-propane diol, ethanol, and any combination.

24. A method for administering a biologically-active agent to an animal in need of the agent, the method comprising administering orally to the animal the composition of claim 2 .

25. A method for preparing a composition comprising mixing:

(A) at least one biologically active agent;

(B) the compound of claim 1 ; and

(C) optionally, a dosing vehicle.

26. A compound having the formula:

or a salt thereof, wherein

R 1 , R 2 , R 3 , and R 4 are independently H, —OH, halogen, C 1 -C 4 alkoxy, C 1 -C 4 alkyl, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, or aryl;

R 1 , R 2 , R 3 , and R 4 are optionally substituted with halogen, —OH, C 1 -C 4 alkoxy, or alkyl; and

R 5 is a C 2 -C 16 branched alkylene, optionally substituted with halogen.

27. A composition comprising:

(A) a biologically active agent; and

(B) at least one compound of claim 26 .