Granular preparations for oral administration
View Patent ↗The present invention provides an oral grain preparation comprising an agent swellable in the mouth as an active component, wherein the preparation has an inner coating layer of a water-soluble cellulose polymer and an outer coating layer of an ethylcellulose on a plain grain having a diameter of 3 to 4 mm. The agent of the present invention is free from sliminess peculiar to cellulose and adherence of each grains in the mouth at taking, and has excellent feeling for taking without an unpleasant feeling such as caused by a large tablet.
1. An oral grain preparation having a diameter of 3 to 4 mm and comprising an anion exchange resin, wherein the preparation has an inner coating layer of a water-soluble cellulose polymer and an outer coating layer consisting essentially of an ethylcellulose, wherein the oral grain preparation is suitable for oral administration, and wherein the outer layer does not contain a water-soluble cellulose polymer.
2. The oral grain preparation according to claim 1 , wherein the anion exchange resin is 2-methylimidazole-epichlorohydrin copolymer.
3. The oral grain preparation according to claim 1 , which is obtained by coating a plain grain comprising an anion exchange resin having a diameter of 3 to 4 mm with a solution of the water-soluble cellulose polymer at an amount of 3.5 to 8% by weight and then coating the plain grain with an aqueous dispersion consisting essentially of ethylcellulose at an amount of 0.5 to 4% by weight, wherein the total coating amount is 5.5 to 8.5% by weight based on the weight of the plain grain.
4. The oral grain preparation according to claim 1 , which is obtained by coating a plain grain comprising an anion exchange resin having a diameter of 3 to 4 mm with a solution of the water-soluble cellulose polymer at an amount of 4 to 6% by weight and then coating the plain grain with an aqueous dispersion consisting essentially of ethylcellulose at an amount of 1 to 2% by weight, wherein the total coating amount is 6 to 8% by weight based on the weight of the plain grain.
5. The oral grain preparation according to claim 1 , wherein the water-soluble cellulose polymer is hydroxypropylmethylcellulose, hydroxypropylcellulose, or methylcellulose.
6. The oral grain preparation according to claim 1 , wherein the ethylcellulose is an aqueous dispersion of a latex aqueous coating agent containing ethylcellulose as a base material.
7. An oral grain preparation having a diameter of 3 to 4 mm comprising an anion exchange resin, which is obtained by coating a plain grain comprising an anion exchange resin having a diameter of 3 to 4 mm with a solution of a water-soluble cellulose polymer, and then coating the plain grain with an aqueous dispersion consisting essentially of an ethylcellulose, wherein the oral grain preparation is suitable for oral administration, and wherein the resulting outer layer does not contain a water-soluble cellulose polymer.
8. The oral grain preparation according to claim 7 , wherein the anion exchange resin is 2-methylimidazole-epichlorohydrin copolymer.
9. The oral grain preparation according to claim 7 , which is obtained by coating the plain grain with the solution of the water-soluble cellulose polymer at an amount of 3.5 to 8% by weight and then coating the plain grain with the aqueous dispersion consisting essentially of ethylcellulose at an amount of 0.5 to 4% by weight, wherein the total coating amount is 5.5 to 8.5% by weight based on the weight of the plain grain.
10. The oral grain preparation according to claim 7 , which is obtained by coating the plain grain with the solution of the water-soluble cellulose polymer at an amount of 4 to 6% by weight and then coating the plain grain with the aqueous dispersion consisting essentially of ethylcellulose at an amount of 1 to 2% by weight, wherein the total coating amount is 6 to 8% by weight based on the weight of the plain grain.
11. The oral grain preparation according to claim 7 , wherein the water-soluble cellulose polymer is hydroxypropylmethylcellulose, hydroxypropylcellulose, or methylcellulose.
12. The oral grain preparation according to claim 7 , wherein the aqueous dispersion consisting essentially of the ethylcellulose is a latex aqueous coating agent containing ethylcellulose as a base material.