Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
View Patent ↗Topical compositions which include urea and an antimicrobial agent, particularly sulfacetamide or metronidazole, are described. Sulfacetamide compositions further including sulfur are also described. Methods for treating dermatological disorders using the compositions are also described.
1. A topical composition for the treatment of a dermatological disorder selected from the group consisting of acne, seborrhea, ingrown hairs, pseudofolliculitis barbae, and hyperpigmented skin, the composition comprising:
a dermatologically effective amount of sulfacetamide or a salt thereof;
a dermatologically effective amount of urea wherein the amount of urea is effective for the treatment of the dermatological disorder;
a dermatologically effective amount of gamma tocopherol; and
a dermatologically acceptable carrier,
wherein the composition is effective for the treatment of the dermatological disorder and the composition comprises about 1 to about 40% by weight urea.
2. The composition of claim 1 , wherein the composition comprises about 10 to about 20% by weight urea.
3. The composition of claim 1 , wherein the composition comprises about 5 to about 20% by weight urea.
4. The composition of claim 1 , wherein the composition comprises about 0.1 to about 10% by weight of gamma tocopherol.
5. The composition of claim 1 , wherein the composition comprises about 10% by weight sulfacetamide or its sodium salt, and about 3% gamma tocopherol.
6. A topical composition for treatment of dermatological disorders according to claim 1 and further comprising sulfur.
7. The composition of claim 6 , wherein the composition comprises about 1 to about 10% of weight sulfur.
8. The composition of claim 6 , wherein the composition comprises about 5% by weight sulfur.