Method of treating fungal conditions of the skin
View Patent ↗Methods of treating fungal conditions and onychomycosis are described which include administration of a safe and effective amount of urea in a topical formulation to an affected area on the skin or around a nail of a patient in need of treatment.
1. A method of treating a fungal condition of the skin, wherein the fungal condition is Tinea pedis or is a condition caused by a dermatophyte, a Trichophyton , an Epidermophyton , and Candida Albicans , comprising:
administering to an affected area of the skin of a patient a composition consisting essentially of urea as the sole active ingredient and a dermatologically acceptable excipient selected from the group consisting of petrolatum or a synthetic or semi-synthetic hydrocarbon, or a semi-solid mixture thereof; a liquid petrolatum or a synthetic or semi-synthetic oleaginous liquid fraction, or a mixture thereof; a C 16-18 aliphatic or branched chain fatty alcohol or fatty acid, or a mixture thereof; glyceryl stearate; xanthan gum; water; and optionally a mixture of a carbomer and triethanolamine, wherein the urea is present in an amount therapeutically effective for treating the fungal condition wherein the urea is present from about 10 to about 60 wt-%.
2. The method of claim 1 , wherein the administering step is carried out by topically applying the composition.
3. The method of claim 1 , wherein the urea is present from about 30 to about 50 wt-% urea.
4. The method of claim 1 , wherein the urea is present from about 10 to about 40 wt-% urea.
5. The method of claim 1 , wherein the composition is in a topical form selected from the group consisting of cream, ointment, solution, lacquer, gel, and foam.
6. The method of claim 1 , wherein the composition is a gel.
7. The method of claim 1 , wherein the urea is present in an amount of about 40 wt-%.
8. The method of claim 7 , wherein the composition is a gel or a cream.