Generation of hematopoietic cells from multipotent neural stem cells
View Patent ↗Multipotent neural stem cell (MNSC) progeny are induced to generate cells of the hematopoietic system by placing the MNSC progeny in a hematopoietic-inducing environment. The hematopoietic-inducing environment can be either ex vivo or in vivo. A mammal's circulatory system provides an in vivo environment that can induce xenogeneic, allogeneic, or autologous MNSC progeny to generate a full complement of hematopoietic cells. Transplantation of MNSC progeny provides an alternative to bone marrow and hematopoietic stem cell transplantation to treat blood-related disorders.
1. A method of generating hematopoietic cells from human multipotent neural stem cell progeny comprising administering said multipotent neural stem cell progeny to a hematopoietic-inducing environment in a human that induces said multipotent neural stem cell progeny to produce said hematopoietic cells, wherein said hematopoietic-inducing environment is selected from the group consisting of the circulatory system, the spleen, and the thymus.
2. The method of claim 1 wherein said human multipotent neural stem cell progeny are derived from human neural tissue.
3. The method of claim 1 wherein said human multipotent neural stem cell progeny are derived from juvenile or adult tissue.
4. The method of claim 1 wherein said human multipotent neural stem cell progeny are derived from tissues surrounding the central nervous system ventricles.