IP Library › Granted Patent US 6,841,547
Granted Patent B2
US 6,841,547 · App. 10/377,088 · Granted Jan 11, 2005

Method for decreasing low density lipoprotein

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Quick Facts
Patent No.
US 6,841,547
App. No.
10/377,088
Granted
Jan 11, 2005
Kind
B2
Abstract

The present invention relates to a method for decreasing elevated serum/plasma LDL-cholesterol levels or LDL-cholesterol levels and CRP levels in a mammal in need thereof. The methods comprises administering an effective amount of a tetracycline formulation. In one embodiment, the tetracycline formulation is a non-antibacterial tetracycline. In another embodiment, the tetracycline formulation is an antibacterial tetracycline at a sub-antibacterial amount.

Claims (20)

1. A method for decreasing elevated serum/plasma low density lipoprotein-cholesterol levels in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a tetracycline formulation.

2. A method according to claim 1 , wherein the tetracycline formulation comprises a non-antibacterial tetracycline.

3. A method according to claim 1 , wherein the tetracycline formulation comprises a antibacterial tetracycline at a sub-antibacterial amount.

4. A method according to claim 3 , wherein the antibacterial tetracycline is doxycycline.

5. A method according to claim 3 , wherein the antibacterial tetracycline is minocycline.

6. A method according to claim 2 , wherein the non-antibacterial tetracycline is CMT-3.

7. A method according to claim 2 , wherein the non-antibacterial tetracycline is CMT-308.

8. A method according to claim 2 , wherein the non-antibacterial tetracycline is CMT-8.

9. A method according to claim 2 , wherein the non-antibacterial tetracycline is CMT-10.

10. A method according to claim 2 , wherein the non-antibacterial tetracycline is CMT-1002.

11. A method for decreasing elevated serum/plasma low density lipoprotein-cholesterol levels and C-reactive protein levels in a mammal in need thereof, the method comprising administering to the mammal an effective amount of a tetracycline formulation.

12. A method according to claim 11 , wherein the tetracycline formulation comprises a non-antibacterial tetracycline.

13. A method according to claim 11 , wherein the tetracycline formulation comprises a antibacterial tetracycline at a sub-antibacterial amount.

14. A method according to claim 13 , wherein the antibacterial tetracycline is doxycycline.

15. A method according to claim 13 , wherein the antibacterial tetracycline is minocycline.

16. A method according to claim 12 , wherein the non-antibacterial tetracycline is CMT-3.

17. A method according to claim 12 , wherein the non-antibacterial tetracycline is CMT-308.

18. A method according to claim 12 , wherein the non-antibacterial tetracycline is CMT-8.

19. A method according to claim 12 , wherein the non-antibacterial tetracycline is CMT-10.

20. A method according to claim 12 , wherein the non-antibacterial tetracycline is CMT-1002.

Assignments (5)
CHANGE OF NAME Recorded Oct 20, 2015
From: COM AFFILIATION, INC.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
Reel/Frame 036900/0190 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 16, 2015
From: ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY
To: COM AFFILIATION, INC.
Reel/Frame 036877/0835 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2003
From: GOLUB, LORNE M. DR.; LEE, HSI-MING DR.; GREENWALD, ROBERT DR.; RYAN, MARIA DR.
To: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
Reel/Frame 014486/0831 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2003
From: BROWN, DAVID DR.
To: ALBERT EINSTEIN COLLEGE OF MEDICINE YESHEVIA UNIVERSITY
Reel/Frame 014318/0624 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2003
From: DESAI, KAVITA, DR.
To: MONTEFIORE MEDICAL CENTER
Reel/Frame 014318/0661 →