IP Library › Granted Patent US 7,015,200
Granted Patent B2
US 7,015,200 · App. 10/381,224 · Granted Mar 21, 2006

Gamma-hydroxybutyrate compositions containing carbohydrate, lipid or amino acid carriers

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 7,015,200
App. No.
10/381,224
Granted
Mar 21, 2006
Kind
B2
Abstract

The present invention provides compositions comprising at least one GHB moiety bonded to at least one physiologically compatible carrier molecule. The compositions can enhance the uptake of the drug, deliver effective therapeutic doses in a time-delayed fashion, or can target specific organs.

Claims (14)

1. A compound of the formula (I):

wherein Y is H, a (C 4 -C 6 )acetal, (C 1 -C 5 )acyl or (C 1 -C 5 )alkyl, X is a carbohydrate and n has a value of 1 to the number of available hydroxyl groups in said carbohydrate, or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 wherein the carbohydrate is a saccharide.

3. The compound of claim 1 wherein Y is H.

4. The compound of claim 1 wherein the carbohydrate is a monosaccharide or a disaccharide.

5. The compound of claim 1 wherein the carbohydrate is a polysaccharide.

6. The compound of claim 4 or 5 wherein the disaccharide or polysaccharide contains at least one CHOH—CHOH moiety that is protected as an acetal or ketal.

7. The compound of claim 1 wherein the carbohydrate is a chemically modified cellulose.

8. The compound of claim 7 wherein the chemically modified cellulose is hydroxypropyl-methylcellulose, hydroxyethylcellulose or hydroxypropylcellulose.

9. The compound of claim 1 wherein the carbohydrate is a chemically modified saccharide.

10. A pharmaceutical composition comprising the compound of claim 1 in combination with a pharmaceutically acceptable carrier.

11. The compound of claim 1 wherein the carbohydrate is a chemically-modified starch.

12. A method for treating a mammal afflicted with a condition or pathology amenable to treatment by gamma-hydroxybutyrate (GHB) comprising administering to said mammal an effective amount of a compound of formula (I):

wherein Y is H or a hydroxyl protecting group, X is a carbohydrate and n has a value of 1 to the number of available hydroxyl groups in said carbohydrate, or a pharmaceutically acceptable salt thereof.

Assignments (9)
SECURITY AGREEMENT Recorded May 5, 2021
From: CAVION, INC.; CELATOR PHARMACEUTICALS, INC.; JAZZ PHARMACEUTICALS IRELAND LIMITED; JAZZ PHARMACEUTICALS, INC.
To: U.S. BANK NATIONAL ASSOCIATION
Reel/Frame 056151/0010 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 11, 2016
From: ORPHAN MEDICAL, LLC
To: JAZZ PHARMACEUTICALS, INC.
Reel/Frame 040282/0878 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 11, 2016
From: JPI COMMERCIAL, LLC
To: JAZZ PHARMACEUTICALS, INC.
Reel/Frame 040282/0819 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 30, 2011
From: SILICON VALLEY BANK
To: JPI COMMERCIAL, LLC
Reel/Frame 027505/0569 →
SECURITY AGREEMENT Recorded Jun 30, 2010
From: JPI COMMERCIAL, LLC
To: SILICON VALLEY BANK
Reel/Frame 024611/0538 →
RELEASE OF SECURITY INTEREST Recorded Jun 30, 2010
From: LB I GROUP, INC.
To: JPI COMMERCIAL, LLC
Reel/Frame 024611/0564 →
SECURITY AGREEMENT Recorded Apr 4, 2008
From: JPI COMMERCIAL, LLC
To: LB I GROUP INC.
Reel/Frame 020753/0871 →
SECURITY INTEREST Recorded Jul 29, 2005
From: TWIST MERGER SUB, INC.
To: LB 1 GROUP INC.
Reel/Frame 016593/0073 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 3, 2003
From: MAMELAK, MORTIMER; HOUGHTON, WILLIAM C.; REARDAN, DAYTON T.; MILLER, BRIAN L.
To: ORPHAN MEDICAL, INC.
Reel/Frame 014648/0612 →