IP Library › Granted Patent US 7,049,128
Granted Patent B2
US 7,049,128 · App. 10/382,758 · Granted May 23, 2006

Platelet glycoprotein Ibα fusion polypeptides and methods of use thereof

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Quick Facts
Patent No.
US 7,049,128
App. No.
10/382,758
Granted
May 23, 2006
Kind
B2
Abstract

The present invention provides compositions and methods for treating or preventing vascular-associated disorders.

Claims (8)

1. An isolated nucleic acid molecule encoding a glycoprotein Ibα polypeptide-immunoglobulin fusion polypeptide comprising the amino acid sequence of SEQ ID NO:5.

2. A vector comprising the nucleic acid molecule of claim 1 .

3. An isolated cell comprising the vector of claim 2 .

4. A method for expressing glycoprotein Ibα polypeptide-immunoglobulin fusion polypeptide comprising the amino acid sequence of SEQ ID NO:5, the method comprising culturing the cell of claim 3 under conditions that result in expression of said fusion polypeptide.

5. A composition comprising the nucleic acid of claim 1 .

6. The nucleic acid molecule of claim 1 , wherein the amino acid sequence of the polypeptide consists of SEQ ID NO:5.

7. A nucleic acid molecule encoding a multimeric polypeptide comprising the polypeptide encoded by the nucleic acid of claim 1 .

8. The nucleic acid molecule of claim 7 , wherein said multimeric polypeptide is a dimer.