Antibodies against cancer antigen TMEFF2 and uses thereof
View Patent ↗Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
1. An isolated antibody or antigen binding fragment thereof comprising:
the heavy chain variable region of SEQ ID NO:26 and the light chain variable region of SEQ ID NO:34.
2. The antibody of claim 1 wherein the antibody is conjugated to a detectable label.
3. The antibody of claim 1 wherein the antibody is conjugated to an effector selected from the group consisting of a toxin, a chemotherapeutic agent and a radioisotope.
4. The antibody of claim 3 wherein the toxin is auristatin.
5. The antibody of claim 1 wherein
the heavy chain variable region is encoded by SEQ ID NO:25 and the light chain variable region is encoded by SEQ ID NO:3.
6. A pharmaceutical composition comprising the antibody of claim 1 and a pharmaceutically acceptable excipient.
7. A pharmaceutical composition comprising the antibody of claim 4 and a pharmaceutically acceptable excipient.