IP Library › Granted Patent US 7,249,601
Granted Patent B2
US 7,249,601 · App. 10/384,285 · Granted Jul 31, 2007

Method for vascular occlusive therapy

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Quick Facts
Patent No.
US 7,249,601
App. No.
10/384,285
Granted
Jul 31, 2007
Kind
B2
Abstract

A method for treating a blood vessel in a wall forming a gastrointestinal tract of a body of a mammal. A solution is introduced from the gastrointestinal tract into the vessel. A nonbiodegradable solid is formed in the vessel from the solution to create an occlusion in the vessel and thus terminate blood flow to the vessel distal of the occlusion.

Claims (32)

1. A method for use in a body of a mammal having an internal wall forming a gastrointestinal tract to treat a blood vessel in the wall comprising introducing a solution from the gastrointestinal tract into the vessel and forming from the solution a nonbiodegradable solid in the vessel to create an occlusion in the vessel and thus terminate blood flow to the vessel distal of the occlusion.

2. The method of claim 1 wherein the solution includes a biocompatible polymer and a biocompatible solvent.

3. The method of claim 1 wherein the solution includes a contrast agent.

4. The method of claim 1 wherein the solution includes a prepolymer and wherein the forming step includes polymerizing the prepolymer in situ to form a nonbiodegradable solid in the wall.

5. The method of claim 1 wherein the introducing step includes extending a needle into the vessel and supplying the solution through the needle into the vessel.

6. The method of claim 5 wherein the introducing step includes the introducing the needle through the mouth and into the gastrointestinal tract.

7. The method of claim 6 wherein the introducing step includes introducing the solution into an enlarged varix in the vessel in the vicinity of the gastroesophageal sphincter.

8. The method of claim 6 wherein the introducing step includes introducing the solution into an ulcer in the vessel.

9. The method of claim 5 wherein the introducing step includes the introducing the needle through the anus and into the anal canal of the gastrointestinal tract.

10. The method of claim 9 wherein the introducing step includes introducing the solution into a hemorrhoid in the vessel in the anal canal.

11. The method of claim 1 wherein the introducing step includes introducing the solution into an enlarged varix in the vessel in the vicinity of the gastroesophageal sphincter.

12. The method of claim 1 wherein the introducing step includes introducing the solution into an ulcer in the vessel.

13. The method of claim 12 further comprising the step of forming at least one implant in the wall in the vicinity of the gastrointestinal tract to create a tamponade.

14. The method of claim 1 wherein the introducing step includes introducing the solution into a hemorrhoid in the vessel in the anal canal.

15. The method of claim 1 wherein the mammal is a human.

16. The method of claim 1 further comprising the step of ligating the vessel.

17. The method of claim 1 further comprising introducing a clotting agent into the vessel.

18. The method of claim 1 further comprising cauterizing the vessel.

19. A method for treating a varix in a gastrointestinal wall of a body of a mammal having a blood vessel in the wall leading to the varix comprising extending a needle through the wall into the blood vessel and introducing a biocompatible prepolymer into the vessel to form an implant in the vessel so as to occlude the vessel and thus limit blood flow to the varix.

20. The method of claim 19 wherein the implant is a nonbiodegradable implant.

21. The method of claim 19 wherein the biocompatible prepolymer is part of a composition having a biocompatible solvent.

22. A method for treating an ulcer in a gastrointestinal wall of a body of a mammal having a blood vessel in the wall leading to the ulcer comprising extending a needle through the wall into the blood vessel and introducing a biocompatible prepolymer into the vessel to form an implant in the vessel so as to occlude the vessel and thus limit blood flow to the ulcer.

23. The method of claim 22 wherein the implant is a nonbiodegradable implant.

24. The method of claim 22 further comprising creating a tamponade in the wall in the vicinity of the ulcer to inhibit bleeding of the ulcer.

25. The method of claim 24 wherein the creating step includes forming a plurality of implants in the wall in the vicinity of the ulcer.

26. The method of claim 25 wherein the biocompatible prepolymer is part of a composition having a biocompatible solvent.

27. A method for treating a hemorrhoid in a rectal wall of a body of a mammal having a blood vessel in the wall leading to the hemorrhoid comprising extending a needle through the wall into the blood vessel and introducing a biocompatible prepolymer into the vessel to form an implant in the vessel so as to occlude the vessel and thus limit blood flow to the hemorrhoid.

28. The method of claim 27 wherein the implant is a nonbiodegradable implant.

29. The method of claim 27 wherein the biocompatible prepolymer is part of a composition having a biocompatible solvent.

30. A method for use in a body of a mammal having an internal wall forming a gastrointestinal tract to treat a blood vessel in the wall comprising injecting a biocompatible prepolymer into the vessel in the wall and forming from such material at least one implant in the vessel so as to create an occlusion in the vessel and thus limit blood flow to the vessel distal of the occlusion.

31. The method of claim 30 wherein the biocompatible prepolymer is part of a composition having a biocompatible solvent.

32. The method of claim 30 further comprising creating a tamponade in the wall in the vicinity of the portion.