Methods for treating aneurysms
View Patent ↗This invention is directed to methods for treating aneurysms wherein the aneurysmal sac is filled with a non-particulate agent or plurality of such agents and/or with a fluid composition which solidifies in situ. Filling of the aneurysmal sac employs sufficient amount of the non-particulate agent or plurality of such agents and/or the fluid composition to inhibit blood flow into the aneurysm sac. In addition, the methods of this invention also provide for non-endogenous isolation of the parent artery proximal and distal to the aneurysmal sac from systemic blood flow of the treated mammal. The combination of these features provides for treatment of the aneurysmal sac while, at the same time, inhibiting aneurysm formation and/or regrowth in the diseased portions of the arterial wall proximal and distal to the treated aneurysm.
1. A method for treating an aneurysm in a mammalian patient which method comprises:
(a) identifying the vascular site of an aneurysm in a mammalian patient wherein said aneurysm comprises an aneurysmal sac formed from the vascular wall of a parent artery and further wherein said aneurysmal sac participates in the systemic blood flow of said patient;
(b) inhibiting systemic blood flow into said aneurysmal sac by filling at least a portion of said sac with a fluid composition and optionally a non-particulate agent or plurality of said agents; and
(c) non-endogenously isolating the parent artery proximal and distal to said aneurysm from systemic blood flow
wherein the fluid composition comprises a biocompatible polymer, a biocompatible contrast agent, and a biocompatible solvent which solubilizes the biocompatible polymer having a viscosity of at least 150 cSt at 40° C.
2. The method of claim 1 , wherein the non-particulate agent or plurality of non-particulate agents comprise metallic coils.
3. The method of claim 2 , wherein the metallic coils are platinum coils.
4. The method of claim 1 , wherein the fluid composition comprises a biocompatible polymer at a concentration of from about 2 to 50 weight percent; a biocompatible contrast agent at a concentration of from about 10 to about 40 weight percent; and a biocompatible solvent from about 10 to 88 weight percent wherein the weight percents of the biocompatible polymer, contrast agent and biocompatible solvent are based on total weight of the complete composition.
5. The method of claim 1 , wherein isolation of the parent artery proximal and distal to said aneurysm from systemic blood flow is accomplished by placement of a stent adjacent to the aneurysmal sac which stent extends in both the proximal and distal directions of the parent artery beyond the aneurysal sac and isolates blood flow to the arterial walls of the parent artery overlayed by the stent.