Treatment of lung disorders

1 . A method of treating acute lung injury in a subject, comprising:

administering by inhalation a therapeutically effective amount of antithrombin III such that the lung injury is treated;

wherein the antithrombin III is administered at a dose of about 10-300 U/kg of body weight; and,

wherein the antithrombin III is administered in the lungs at the site of the proximate acute injury.

2 . The method of claim 1 , wherein the lung injury is septic acute lung injury.

3 . The method of claim 1 , wherein the lung injury is acute respiratory distress syndrome (ARDS).

4 . The method of claim 1 , wherein the lung injury is in response to exposure to a viral agent.

5 . The method of claim 4 , wherein said viral agent is Pseudomonas pneumonia.

6 . The method of claim 1 , wherein the lung injury is in response to smoke or smoke and asbestos.

7 . The method of claim 1 , wherein the antithrombin III is administered using an ultrasonic nebulizer.

8 . The method of claim 1 , wherein the antithrombin III is plasma derived antithrombin III.

9 . The method of claim 1 , wherein the antithrombin III is recombinantly produced antithrombin III.

10 . The method of claim 9 , wherein the recombinantly produced antithrombin III is transgenically produced antithrombin III.

11 . The method of claim 1 , wherein the subject is administered more than one dose of the antithrombin III.

13 . The method of claim 1 , wherein the antithrombin III is administered at a dose of about 25-125 U/kg of body weight.

14 . A method of treating acute lung injury in a subject, comprising:

administering by inhalation a therapeutically effective amount of antithrombin III such that the lung injury is treated; and,

wherein said lung injury is in response to the activity of Pseudomonas aeruginosa ; and,

wherein the antithrombin III administered is transgenically produced antithrombin III; and

wherein the antithrombin III is administered at a dose of about 10-300 U/kg of body weight.