Method, instruments, and kit for autologous transplantation
View Patent ↗An implantable article for cartilage repair by implantation in an animal. The implantable article includes a support matrix, and chondrocyte cells and a bio-compatible adhesive adhered to an edge of the support matrix, wherein the support matrix is absorbable by the animal. The support matrix is a biocompatible material such as collagen, and the adhesive is autologous fibrin.
1. An implantable article for cartilage repair by implantation in an animal comprising a support matrix, and a mixture of chondrocyte cells and a bio-compatible adhesive adhered to a surface of said support matrix, wherein said support matrix is absorbable by the animal.
2. The implantable article of claim 1 , wherein said support matrix is a sheet-like member capable of supporting growth of the chondrocyte cells and of providing physical integrity to the implantable article to facilitate manipulation thereof.
3. The implantable article of claim 1 , wherein said support matrix comprises polypeptides or proteins.
4. The implantable article of claim 1 , wherein said support matrix is collagen.
5. The implantable article of claim 4 , wherein said collagen is selected from the group consisting essentially of equine, porcine, bovine, ovine and chicken collagen.
6. The implantable article of claim 4 , wherein said collagen is collagen Type II.
7. The implantable article of claim 1 , wherein said support matrix is solid.
8. The implantable article of claim 1 , wherein said support matrix is gel-like.
9. The implantable article of claim 4 , wherein said collagen is collagen Type I.
10. The implantable article of claim 1 , wherein said implantable article is reversibly deformable.
11. The implantable article of claim 1 , wherein said support matrix has a rough side.
12. The implantable article of claim 11 , wherein said rough side is porous.
13. The implantable article of claim 1 , wherein said support matrix has a smooth side.
14. The implantable article of claim 1 , wherein said support matrix has a rough and a smooth side.
15. The implantable article of claim 1 , wherein said chondrocyte cells and said bio-compatible adhesive are in an admixture.
16. The implantable article of claim 1 , further wherein said support matrix has a hemostatic effect.
17. The implantable article of claim 16 , wherein said support matrix is a sheet-like member capable of supporting growth of the chondrocyte cells and of providing physical integrity to the implantable article to facilitate manipulation thereof.
18. The implantable article of claim 16 , wherein said support matrix comprises polypeptides or proteins.
19. The implantable article of claim 16 , wherein said support matrix is collagen.
20. The implantable article of claim 19 , wherein said collagen is selected from the group consisting essentially of equine, porcine, bovine, ovine and chicken collagen.
21. The implantable article of claim 16 , wherein said support matrix is solid.
22. The implantable article of claim 16 , wherein said support matrix is gel-like.
23. The implantable article of claim 19 , wherein said collagen is collagen Type I.
24. The implantable article of claim 19 , wherein said collagen is collagen Type II.
25. The implantable article of claim 16 , wherein said implantable article is reversibly deformable.
26. The implantable article of claim 16 , wherein said support matrix has a rough side.
27. The implantable article of claim 26 , wherein said rough side is porous.
28. The implantable article of claim 16 , wherein said support matrix has a smooth side.
29. The implantable article of claim 16 , wherein said support matrix has a rough and a smooth side.
30. The implantable article of claim 16 , wherein said chondrocyte cells and said bio-compatible adhesive are in an admixture.