Percutaneous transluminal endarterectomy
View Patent ↗Methods and devices for performing intravascular endarterectomy. Methods includes intravascularly advancing a catheter having a carbon dioxide delivering distal end past a plaque-occluded vessel site, passing the distal end between the plaque and vessel wall. Other methods include intravascularly advancing paddles between plaque and vessel walls, including ultrasonic imaging paddles, ultrasonic vibrating paddles, and mechanically vibrating paddles. Some methods include providing intravascular devices having radially expandable jaws or paddles, and advancing those jaws or paddles along vessel walls to separate plaque from vessel walls. Still other methods include providing an anchoring guide catheter adapted to establish a suction grip around the left coronary artery ostium, and to use the anchored guide catheter to support intravascularly introduced endarterectomy devices operating on plaque in the left main coronary artery. One method utilizes retroperfusion of the coronary arteries to allow the anchoring guide catheter to remain in position for longer periods. Scissors-type expanding devices and stents for use after endarterectomy procedures are also provided.
1. A percutaneous method for separating plaque from a target site vessel interior wall, the method comprising the steps of:
providing an elongate tubular member having a distal end, a proximal region, a lumen therethrough, and at least one distal orifice in fluid communication with the lumen and disposed in the tubular member distal end;
providing a carbon dioxide source in fluid communication with the elongate tubular member lumen in the proximal region;
inserting the tubular member distal end into the vasculature at a remote entry site;
advancing the tubular member distal end through the vasculature to near the target site;
infusing the carbon dioxide into the lumen and through the distal orifice; and
separating the plaque from the vessel wall by further advancing the tubular member distal end along the target site vessel wall while expelling carbon dioxide from the tubular member distal end.
2. A percutaneous method as recited in claim 1 , wherein the inserting tubular member step includes inserting at the remote entry site at least 100 centimeters from the target site.
3. A percutaneous method as recited in claim 2 , wherein the distal end is blunt, such that the separating step is achieved using the blunt end.
4. A percutaneous method as recited in claim 3 , wherein the separating step is achieved by separating the plaque from the vessel wall along a region of weakness by infusing the carbon dioxide.
5. A percutaneous method as recited in claim 4 , wherein the tubular member distal end has a bulbous shape.
6. A percutaneous method as in claim 5 , wherein the tubular member bulbous distal end has an outer diameter at least 50 percent greater than the outer diameter of a tubular member distal region disposed just proximal of the bulbous distal end.
7. A percutaneous method as in claim 2 , wherein the tubular member includes a distal pressure transducer for measuring vessel fluid pressure near the distal end, and the method includes adjusting carbon dioxide inflow in response to a signal from the distal pressure transducer.
8. A percutaneous method as in claim 2 , wherein the target site is within a coronary artery, and the remote entry site is located further away than the chest area.
9. A percutaneous method for separating plaque from a target site vessel wall, the method interior wall, the method comprising the steps of:
providing an elongate tubular member having a distal region and a proximal region, wherein the distal region has a distal paddle having a width and a thickness, wherein the width is larger than the thickness, wherein the paddle has a blunt distal edge;
inserting the tubular member distal paddle into the vasculature at a remote entry site;
advancing the tubular member distal paddle through the vasculature to near the target site; and
separating the plaque from the vessel wall by further advancing the tubular member distal paddle blunt distal edge along the target site vessel wall.
10. A percutaneous method as recited in claim 9 , wherein inserting paddle step includes inserting the paddle at the remote entry site at least 100 centimeters from the target site.