IP Library Granted Patent US 6,974,445
Granted Patent B2
US 6,974,445 · App. 10/398,764 · Granted Dec 13, 2005

Implantable medical device for delivering a liquid

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Quick Facts
Patent No.
US 6,974,445
App. No.
10/398,764
Granted
Dec 13, 2005
Kind
B2
Abstract

The invention concerns an implantable device ( 1 ) for delivering medicines in liquid form comprising: a reservoir ( 2 ) provided with an inlet ( 3 ) and an outlet ( 10 ), said reservoir ( 2 ) being adapted to expel the liquid; a variable volume chamber ( 5 ) provided with an inlet ( 11 ) and an outlet ( 12 ), the volume of the variable volume chamber ( 5 ) being in particular smaller than that of the reservoir ( 2 ); a first conduit ( 6 ) communicating the outlet ( 10 ) of the reservoir ( 2 ) with the inlet ( 11 ) of the variable volume chamber ( 5 ) to fill the latter; a second conduit ( 8 ) whereof one of the ends is connected on the outlet ( 12 ) of the variable volume chamber ( 5 ).

Claims (29)

1. An implantable device ( 1 ) for administering medicines in liquid form, comprising:

a reservoir ( 2 ); a variable-volume chamber ( 5 ) having a volume determined by a position of at least a first movable volume limiter;

a first conduit ( 8 ) connecting the reservoir ( 2 ) to the variable-volume chamber ( 5 ) in order to fill the latter, said first conduit ( 8 ) comprising a valve;

a second conduit ( 8 ) coupled to the variable-volume chamber ( 5 ), the second conduit having an outlet end adapted to be disposed at a treatment site; and

a control box coupled to the valve and the at least first volume limiter, the control box programmed to control actuation of the valve and positioning of the first movable volume limiter.

2. The device of claim 1 wherein the valve is activated when the variable-volume chamber ( 5 ) attains a predetermined volume.

3. The device of claim 1 , wherein the control box is programmed to actuate the valve at regular time intervals Δt.

4. The device of claim 1 , wherein the resistance to the flow of the fluid in the second conduit ( 8 ) is greater than that of the first conduit ( 6 ).

5. The device of claim 1 , wherein the control box is configured to receive control parameters telemetrically.

6. The device of claim 1 , wherein a volume of the reservoir ( 2 ) is at least 5 times greater than that of the variable-volume chamber ( 5 ).

7. The device of claim 1 , further comprising a second movable volume limiter.

8. The device of claim 7 , wherein the control box further is programmed to control a position of the second movable volume limiter.

9. The device of claim 1 wherein the reservoir is elastically deformable.

10. The device of claim 7 wherein the second movable volume limiter further comprises a sensor, the sensor generating a signal that triggers expulsion of medicine from the variable-volume chamber.

11. An implantable pump for delivery of a drug, the implantable pump comprising:

a reservoir that deforms elastically when it is filled with the drug;

a chamber having a volume determined by a position of a first movable volume limiter;

a valve interposed between the reservoir and the chamber, the valve configured to be electrically activated;

an outlet catheter in fluid communication with the chamber; and

a control box programmed to control actuation of the valve and positioning of the first movable volume limiter.

12. The pump of claim 11 wherein the control box is configured to receive control parameters telemetrically.

13. The pump of claim 11 wherein the reservoir further comprises a resealable septum.

14. The pump of claim 11 wherein the valve is activated when the variable-volume chamber attains a predetermined volume.

15. The pump of claim 11 wherein the control box is programmed to actuate the valve at regular time intervals Δt.

16. The pump of claim 11 , wherein a volume of the reservoir is at least 5 times greater than that of the chamber.

17. The pump of claim 11 wherein the chamber is elastically deformable.

18. The pump of claim 11 , further comprising a second movable volume limiter.

19. The pump of claim 18 wherein the control box further is programmed to control a position of the second movable volume limiter.

20. The pump of claim 11 further comprising a sensor that triggers expulsion of medicine from the chamber.

Assignments (13)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY US, INC. (F/K/A APOLLO ENDOSURGERY, INC.)
Reel/Frame 048622/0343 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY US, INC. (F/K/A APOLLO ENDOSURGERY, INC.)
Reel/Frame 048622/0328 →
CHANGE OF NAME Recorded Mar 27, 2017
From: APOLLO ENDOSURGERY, INC.
To: APOLLO ENDOSURGERY US, INC.
Reel/Frame 042106/0912 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY US, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0821 →
CHANGE OF NAME Recorded Jul 2, 2015
From: ALLERGAN MEDICAL SA
To: ALLERGAN MEDICAL SARL
Reel/Frame 036077/0187 →
TERMINATION OF PATENT SECURITY INTEREST (RECORDED ON 12/3/13 AT REEL/FRAME 031756/0729 AND ON 1/2/14 AT REEL/FRAME 031910/0460) Recorded Mar 2, 2015
From: OXFORD FINANCE LLC, AS AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 035120/0740 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Mar 2, 2015
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 035120/0843 →
CORRECTIVE ASSIGNMENT TO CORRECT THE EXECUTION DATE PREVIOUSLY RECORDED ON REEL 031861 FRAME 0521. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT OF ASSIGNORS INTEREST. Recorded Jan 7, 2014
From: ALLERGAN MEDICAL SARL
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 031925/0046 →
SECURITY AGREEMENT Recorded Jan 2, 2014
From: APOLLO ENDOSURGERY, INC.
To: OXFORD FINANCE LLC, AS AGENT
Reel/Frame 031910/0460 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 31, 2013
From: ALLERGAN MEDICAL SARL
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 031861/0521 →
CHANGE OF NAME Recorded Jan 11, 2008
From: ENDOART SA
To: ALLERGAN MEDICAL S.A.
Reel/Frame 020353/0344 →
CHANGE OF NAME Recorded Oct 5, 2007
From: ENDOART S.A.
To: ALLERGAN MEDICAL S.A.
Reel/Frame 019920/0753 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 10, 2003
From: STERGIOPULOS, NIKOLAUS
To: ENDOART SA
Reel/Frame 014397/0216 →