Synergistic antioxidant combination of delta tocols and polyphenols
View Patent ↗A source of δ-tocotrienol and/or-tocopherol acts synergistically with an antioxidant source comprising polyphenols, to effect suppression of LDL oxidation in serum. The combination of these two antioxidant sources has wide-ranging applications in treatment of medical conditions arising from free radical generation, including arteriosclerosis and cancer.
1. A composition comprising:
(a) a source of δ-tocol comprising greater than 2% by weight said δ-tocol; and
(b) polyphenols,
wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein said composition is substantially free of α-tocopherol.
2. A composition according to claim 1 , which in a unit dosage comprises 0.5 to 50 mg δ-tocol.
3. A composition comprising in a daily dosage:
(a) at least 5 mg δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof; and
(b) polyphenols,
wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1 , and wherein said composition is substantially free of α-tocopherol.
4. A composition comprising in a daily dosage:
(a) at least 5 mg of δ-tocol selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof; and
(b) polyphenols other than citrus flavonoids,
wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and wherein said composition is substantially free of α-tocopherol.
5. The composition according to claim 1 , further comprising a catechin.
6. The composition according to claim 1 , further comprising α-tocopherol, wherein a weight ratio of δ-tocol to α-tocopherol is greater than 0.65.
7. The composition according to claim 1 , wherein δ-tocol is a Tocotrienol Rich Fraction (TRF) source selected from the group consisting of palm oil or rice bran oil and a blend of tocopherols, and said polyphenols is selected from the group consisting of green tea, Pu Erh tea, extracts thereof and mixtures thereof.
8. The composition according to claim 1 , which is substantially free of tocols other than δ-tocols.
9. The composition according to claim 1 , wherein an antioxidant property of the composition is greater in the case that said polyphenols consist of a single polyphenolic antioxidant source than in the case that said polyphenols include more than one polyphenolic antioxidant source.
10. The composition according to claim 1 , further comprising a nutritionally quantity of a carbohydrate, a fat, a fiber or a protein.
11. The composition according to claim 1 , further a pharmaceutically acceptable carrier.
12. The composition according to claim 11 , further comprising antioxidants consisting essentially of said δ-tocol and said polyphenols.
13. A kit comprising:
(a) a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol; and
(b) an antioxidant source comprising polyphenols,
for separate, sequential or simultaneous administration,
wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said kit is substantially free of α-tocopherol.
14. The composition according to claim 1 , further a cosmetically acceptable carrier.
15. A method of treating a medical condition caused by the generation of free radicals comprising the step of administering to a person in need of such treatment an effective amount of a source of δ-tocol comprising greater than 2% by weight said δ-tocol and polyphenols, wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, and said δ-tocol comprises δ-tocopherol when said polyphenols comprises citrus flavonoids, and wherein administration is substantially free of α-tocopherol.
16. The method of claim 15 , wherein said medical condition is selected from the group consisting of arteriosclerosis, rheumatism and cancer.
17. The method of claim 15 , wherein said medical condition is caused by physical activity, sun exposure or smoking.
18. A method of preventing spoilage in a food or beverage product comprising the step of using a composition comprising a source of δ-tocol preferably comprising greater than 2% by weight δ-tocol and an antioxidant source comprising polyphenols as a preservative wherein a dry weight ratio of said polyphenols to said δ-tocol is in the range of 25:1 to 50:1, wherein said δ-tocol is selected from the group consisting of δ-tocopherol, δ-tocotrienol and mixtures thereof, and wherein said composition is substantially free of α-tocopherol.