Method for producing an extract from cannabis plant matter, containing a tetrahydrocannabinol and a cannabidiol and cannabis extracts
View Patent ↗The invention relates to a method for producing an extract from cannabis plant matter, containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof. According to said method, the dried plant matter is ground and subjected to a CO 2 extraction and the primary extract obtained is separated. The invention method permits Δ 8 or Δ 9 tetrahydrocannabinol to be selectively obtained both from industrial hemp and from drug-producing hemp, optionally after dissolving the primary extract in ethanol, separating undesirable waxes and removing the solvent under reduced pressure.
1. A process for producing cannabidiol from a primary extract from industrial hemp plant material containing tetrahydrocannabinol and cannabidiol and optionally the carboxylic acids thereof, wherein said primary extract is obtained by a process comprising
extracting dried comminuted industrial hemp plant material by means of CO 2
(a) under supercritical pressure and temperature conditions at a temperature in a range of approx. 31° C. to 80° C. and at a pressure in a range of approx 75 bar or 500 bar, or
(b) in liquefied form in the subcritical range at a temperature of approx. 20° C. to 30° C. and a supercritical pressure of approx. 100 bar to 350 bar; or
(c) in liquefied form under subcritical pressure and temperature conditions; and
separating the obtained primary extract out under subcritical conditions or under conditions subcritical in terms of pressure and supercritical in terms of temperature; and
wherein said primary extract contains reduced proportions of at least monoterpene and sesquiterpene hydrocarbons, alkaloids, flavonoids and chlorophylls; and
wherein process for producing cannabidiol from a primary extract comprises
decarboxylating cannabidiolic acid and tetrahydrocannabidiolic acid in said primary extract into cannabidiol and tetrahydrocannabinol through increase in temperature; and
dissolving the decarboxylated primary extract in the CO 2 extracting agent used, and in this condition treating by means of a high-pressure vessel charged with a catalyst for anellation of cannabidiol into tetrahydrocannabinol and a water-binding agent, wherein cannabidiol is reacted to give tetrahydrocannabinol; and
separating the product enriched in tetrahydrocannabinol at pressure and temperature conditions subcritical for CO 2 .
2. A process for producing cannabidiol from a primary extract from industrial hemp plant material containing tetrahydrocannabinol and cannabidiol
and optionally the carboxylic acids thereof, wherein said primary extract is obtained by a process comprising
extracting dried comminuted industrial hemp plant material by means of CO 2
(a) under supercritical pressure and temperature conditions at a temperature in a range of approx. 31° C. to 80° C. and at a pressure in a range of approx. 75 bar or 500 bar, or
(b) in the subcritical range at a temperature of approx. 20° C. to 30° C. and a supercritical pressure of approx. 100 bar to 350 bar; or
(c) under subcritical pressure and temperature conditions; and
separating the obtained primary extract out under subcritical conditions or under conditions subcritical in terms of pressure and supercritical in terms of temperature; and
wherein said primary extract contains reduced proportions of at least monoterpene and sesquiterpene hydrocarbons, alkaloids, flavonoids and chlorophylls; and
wherein process for producing cannabidiol from a primary extract comprises
decarboxylating cannabidiolic acid and tetrahydrocannabidiolic acid in said primary extract into cannabidiol and tetrahydrocannabinol through increase in temperature; and
subsequently separating the cannabidiol through column chromatography on silica gel or preparative high-pressure liquid chromatography.
3. A process for producing an extract containing tetrahydrocannabinol, cannabidiol and optionally the carboxylic acids thereof from dried comminuted industrial hemp plant material, comprising
(1) subjecting said plant material to a stream of CO 2
(1a) under supercritical pressure and temperature conditions at a temperature in a range of approx. 31° C. to 80° C. and at a pressure in a range of approx. 75 bar or 500 bar, or
(1b) in liquefied form in the subcritical range at a temperature of approx. 20° C. to 30° C. and a supercritical pressure of approx. 100 bar to 350 bar; or
(1c) in liquefied found under subcritical pressure and temperature conditions; to extract cannabinoid components;
(2) reducing the pressure and/or temperature of the extract loaded CO 2 in at least two steps, wherein
(2a) in a first step pressure and/or temperature are reduced whereby monoterpenes and sesquiterpenes are separated from tetrahydrocannabinol and cannabidiol by differential solubility,
(2b) in a subsequent step pressure is reduced to a pressure subcritical for CO 2 , whereby tetrahydrocannabinol and cannabidiol are separated from said CO 2 ,
(2c) subjecting the CO 2 extracted from step (2b) to increased pressure and temperature and recycling said CO 2 to step (1).
4. The process of claim 3 , wherein step (2) further comprises exposure to adsorbent or absorbent to remove alkaloids, flavinoids, and chlorophylls.