Vaccine composition comprising an antigen and a peptide having adjuvant properties
View Patent ↗The invention relates to a vaccine which comprises at least one antigen and a peptide comprising a sequence R 1 —XZXZ N XZX—R 2 , whereby N is a whole number between 3 and 7, preferably 5, X is a positively charged natural and/or non-natural amino acid residue, Z is an amino acid residue selected from the group consisting of L, V, I, F and/or W, and R 1 and R 2 are selected independantly one from the other from the group consisting of —H, —NH 2 , —COCH 3 , —COH, a peptide with up to 20 amino acid residues or a peptide reactive group or a peptide linker with or without a peptide; X—R 2 may also be an amide, ester or thioester of the C-terminal amino acid residue, as well as the use of said peptide for the preparation of an adjuvant for enhancing the immune response to at least one antigen.
1. A vaccine comprising at least one antigen and at least one peptide consisting of the sequence H—KLKLLLLLKLK—H (SEQ ID NO: 1).
2. The vaccine of claim 1 , further defined as comprising at least one further immune response stimulating substance.
3. The vaccine of claim 1 , further defined as comprising at least one immunostimulatory nucleic acid.
4. The vaccine of claim 3 , wherein the immunostimulatory nucleic acid is further defined as an oligodeoxynucleotide containing deoxyinosine, an oligodeoxynucleotide containing deoxyuridine, an oligodeoxynucleotide containing at least one CG motif, or an inosine and cytidine containing nucleic acid molecule.
5. A pharmaceutical composition comprising at least one antigen and a peptide consisting of the sequence H—KLKLLLLLKLK—H (SEQ ID NO: 1).