Methods and compositions of novel triazine compounds
View Patent ↗The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells. The present invention relates to compounds that inhibit smooth muscle proliferation. In particular, the present invention is directed to compounds that inhibit smooth muscle cell proliferation by modulating HSPGs such as Perlecan. The present invention further relates to the use of compounds to treat vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis.
1. A compound selected from:
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,35]triazin-2-ylamino]-methyl}-cyclopentanone,
N-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-guanidine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethanone,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidine-1-carboxylic acid methyl ester,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-cyclopentylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-pyrazolidin-1-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-3-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-6-(1-ethyl-pyrrolidin-2-ylmethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N′-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(pyrrolidin-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-piperidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
1-Ethyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-yl] ester,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
N-(3-Chloro-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Bromo-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-( 1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(2-methyl-pentylamino)[1,3,5]triazin-2-ylamino]-2-methoxy-benzenesulfonic acid,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-methyxy-benzonitrile,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenol,
Sodium; 2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenolate,
N-(3-Chloro-4-ethoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(2-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-yl methyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenolate,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxymethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfinylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfonylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-benzenethiol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methoxy-phenyl)-N″-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N′-methyl-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(tetrahydro-pyrrolo[1,2-c]imidazol-2-yl)-[1,3,5]triazine-2,4-diamine,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxymethyl) ester,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl) ester,
Phosphoric acid mono-(2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenoxymethyl) ester,
N-Cyclohexy[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methylamino-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Acetic acid 4-{4-(cyclohexylmethylamino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
N-(4-Amino-3-fluoro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-dimethylamino-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(4-Amino-3-chloro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-isopropoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-cyclopropoxy-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-cyclopropoxy-phenyl)-N′-Cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-ethyl-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methyl-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4trifluoromethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-trifluoromethoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-ethyl-oxazolidin-4-ylmethyl)-N″-(4-trifluoromethoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methyl-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-difluoro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2,6-difluoro-phenol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-fluoro-5methoxy-pyridin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(5-fluoro-6methoxy-pyridin-3-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(8-fluoro-chroman-6-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-3-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-2-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-pyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-N′-piperidin-4-ylmethyl-[1,3,5]triazine2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiomorpholin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-1 lambda*6*-thiomorpholin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiopyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-hexahydro-1 lambda“6”-thiopyran-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Benzyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-hydroxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-nitro-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(4-fluoro-benzyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopenty[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohex-2-enylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopropylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
′3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino) -[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(2-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(2-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
4-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
N-(4-Amino-cyclohexylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclohexylmethyl)-N′-(1ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cycloheptylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.1]hept-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.2]oct-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Cyclohexyl-1-methyl-ethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiophen-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-ethoxy-phenyl)-N″-(1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2,3-dihydro-1H-indol-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-dimethylamino-ethyl)-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
Pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
1-Methyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
2-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-hexahydro-pyrrolo[1,2-c]imidazol-1-one,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyrrolidine-2,5-dione,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-imidazolidine-2,4-dione,
3-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-thiazolidine-2,5-dione,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-1-methyl-pyrrolidinium; chloride,
1-Acetyl-2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-oxazol-5-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrimidin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(2-Amino-pyrimidin-4-ylmethyl)-N1-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-methoxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-hydroxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-hydroxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(2,4-dioxo-thiazolidin-5-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenolate,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium; bromide,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoic acid,
Sodium; 5-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoate,
3-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid-{4-(cyclohexylmethyl-amino)-6-[(1ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
3-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy)-ethoxy)-propionic acid 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenyl ester,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-phenyl)-[1,3,5]triazine-2,4,6-triamine,
OH2-{2-[2-(4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxy)-ethoxy]-ethoxy)-ethanol,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-pyrrolidin-1-yl)-3-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino-methyl}-pyrrolidin-1-yl)-3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
2-(2-{2-[2-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethoxy]-ethoxy}-ethoxy)-ethanol,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-[1-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-pyrrolidin-2-ylmethyl]-[1,3,5]triazine-2,4,6-triamine,
3-Carboxy-propionate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium,
3-Carboxy-acrylate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium,
N-Cyclohexylmethyl-6-(2-dimethylamino-ethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(oxazol-5-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-Benzyloxy-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-1H-pyrrol-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(furan-2-ylmethoxy-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-(Bicyclo[2.2.2]oct-2-yloxy)-N-cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-pyrrolidin-2-yloxy)-[1,3,5]triazine-2,4-diamine,
4-[4-[(1-Ethyl-pyrrolidin-2-yl methyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-cyclohexanol,
4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-phenol,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-(4-hydroxy-phenyl)-acetic acid,
Cyclohexyl-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-acetic acid,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl-acetic acid,
6-(2-Amino-1-phenyl-ethoxy)-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
2-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-2-phenyl-ethanol,
N-(1-Benzyl-pyrrolidin-2-ylmethyl)N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Amino-phenyl-acetic acid 4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
Trifluoro-acetate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium,
2-Cyclohexyl-2-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-ethanol, or a stereoisomer thereof, a salt thereof, or a combination thereof.
2. A composition comprising a pharmaceutically acceptable carrier and a compound selected from:
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,35]triazin-2-ylamino]-methyl}-cyclopentanone,
N-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-guanidine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethanone,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidine-1-carboxylic acid methyl ester,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-cyclopentylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-ethyl-pyrazolidin-1-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-3-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-6-(1-ethyl-pyrrolidin-2-ylmethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(hexahydro-pyrrolo[1,2-a]pyrazin-2-yl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-N′-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(pyrrolidin-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(1-ethyl-piperidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
1-Ethyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-yl] ester,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
N-(3-Chloro-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Bromo-4-methoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(2-methyl-pentylamino)[1,3,5]triazin-2-ylamino]-2-methoxy-benzenesulfonic acid,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-methoxy-benzonitrile,
4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino)-2-fluoro-phenol,
Sodium; 2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenolate,
N-(3-Chloro-4-ethoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(2-methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-yl methyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenolate,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfinylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methanesulfonylmethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methylsulfanyl-phenyl)-[1,3,5]triazine-2,4,6-triamine, 4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-benzenethiol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methoxy-phenyl)-N″-methyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N′-methyl-N″-pyrrolidin-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(tetrahydro-pyrrolo[1,2-c]imidazol-2-yl)-[1,3,5]triazine-2,4-diamine,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenoxymethyl) ester,
Phosphoric acid mono-(4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl) ester,
Phosphoric acid mono-(2-chloro-4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-phenoxymethyl) ester,
N-Cyclohexy[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methylamino-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Acetic acid 4-{4-(cyclohexylmethylamino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
N-(4-Amino-3-fluoro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-dimethylamino-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(4-Amino-3-chloro-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-isopropoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-cyclopropoxy-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-cyclopropoxy-phenyl)-N′-Cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(4-ethyl-3-fluoro-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4methyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methyl-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4trifluoromethoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-methoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-trifluoromethoxy-phenyl)-N′-cyclohexylmethyl-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-ethyl-oxazolidin-4-ylmethyl)-N″-(4-trifluoromethoxy-3-trifluoromethyl-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methyl-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3,5-dichloro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3, 5-difluoro-4-methoxy-phenyl)-N″-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine, 4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2,6-difluoro-phenol,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(4-fluoro-5methoxy-pyridin-2-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(5-fluoro-6methoxy-pyridin-3-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(8-fluoro-chroman-6-yl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-3-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
6-(4-Amino-2-fluoro-phenoxy)-N-cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-pyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-6-(3-fluoro-4-methoxy-phenoxy)-N″-piperidin-4-ylmethyl-[1,3,5]triazine2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiomorpholin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-1 lambda*6*-thiomorpholin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiopyran-4-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1,1-Dioxo-hexahydro-1 lambda“6”-thiopyran-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Benzyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-nitro-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(4-fluoro-benzyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopenty[methyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohex-2-enylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclopropylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-benzyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclopentanol,
N-(2-Amino-cyclopentylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(4-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-(2-methyl-cyclohexylmethyl)-[1,3,5]triazine-2,4,6-triamine,
2-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
3-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
4-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-cyclohexanol,
N-(4-Amino-cyclohexylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(3-Amino-cyclohexylmethyl)-N′-(1ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cycloheptylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo [2.2.1]hept-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Bicyclo[2.2.2]oct-2-yl-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Aza-bicyclo[2.2.2]oct-3-yl)-N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-(1-Cyclohexyl-1-methyl-ethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-thiophen-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(tetrahydro-furan-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-ethoxy-phenyl)-N″-(1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-(1-methyl-1H-pyrrol-2-ylmethyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2,3-dihydro-1H-indol-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
N-Cyclohexylmethyl-N′-(2-dimethylamino-ethyl)-N″-(3-fluoro-4-methoxyphenyl)-[1,3,5]triazine-2,4,6-triamine,
Pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
Pyrrolidine-2-carboxylic acid 4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
1-Methyl-pyrrolidine-2-carboxylic acid [4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-amide,
2-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-hexahydro-pyrrolo[1,2-c]imidazol-1-one,
1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-pyrrolidine-2,5-dione, 1-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-imidazolidine-2,4-dione,
3-[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl]-thiazolidine-2,5-dione,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-1-methyl-pyrrolidinium; chloride,
1-Acetyl-2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-furan-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-thiophen-2-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-oxazol-5-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(3-Chloro-4-methoxy-phenyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-imidazol-1-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-N″-pyrimidin-4-ylmethyl-[1,3,5]triazine-2,4,6-triamine,
N-(2-Amino-pyrimidin-4-ylmethyl)-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
5-{[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-methoxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-hydroxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
5-{[4-(3-Chloro-4-hydroxy-phenylamino)-6-(cyclohexylmethyl-amino)-[1,3,5]triazin-2-ylamino]-methyl}-thiazolidine-2,4-dione,
Sodium; 4-{4-(cyclohexylmethyl-amino)-6-[(2,4-dioxo-thiazolidin-5-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenolate,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium; chloride,
2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium; bromide,
5-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-methoxy-benzoic acid,
Sodium; 5-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2 -methoxy-benzoate,
3-(2-{2-[2-(2-Hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-propionic acid-{4-(cyclohexylmethyl-amino)-6-[(1 ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino}-2-fluoro-phenyl ester,
3-(2-{2-[2-(2-Methoxy-ethoxy)-ethoxy]-ethoxy)-ethoxy)-propionic acid 4-{4-(cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5triazin-2-ylamino)-2-fluoro-phenyl ester,
N-Cyclohexylmethyl-N′-(1-ethyl-pyrrolidin-2-ylmethyl)-N″-(3-fluoro-4 {2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-phenyl)-[1,3,5]triazine-2,4,6-triamine,
.OH2-{2-[2-(4-{4-(Cyclohexylmethyl-amino)-6-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-[1,3,5]triazin-2-ylamino }-2-fluoro-phenoxy)-ethoxy]-ethoxy)-ethanol,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-pyrrolidin-1-yl)-3 -{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
1-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy)-propan-1-one,
2-(2-{2-[2-(2-{[4-(Cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-pyrrolidin-1-yl)-ethoxy]-ethoxy}-ethoxy)-ethanol,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-N″-[1-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethyl)-pyrrolidin-2-ylmethyl]-[1,3,5]triazine-2,4,6-triamine,
3-Carboxy-propionate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium,
3-Carboxy-acrylate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-methyl}-1-ethyl-pyrrolidinium,
N-Cyclohexylmethyl-6-(2-dimethylamino-ethoxy)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-(1-Ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-6-(oxazol-5-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-Benzyloxy-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-1H-pyrrol-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(furan-2-ylmethoxy-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(thiophen-2-ylmethoxy)-[1,3,5]triazine-2,4-diamine,
6-(Bicyclo[2.2.2]oct-2-yloxy)-N-cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
N-Cyclohexylmethyl-N′-(3-fluoro-4-methoxy-phenyl)-6-(1-methyl-pyrrolidin-2-yloxy)-[1,3,5]triazine-2,4-diamine,
4-[4-[(1-Ethyl-pyrrolidin-2-yl methyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-cyclohexanol,
4-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yloxymethyl]-phenol,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-(4-hydroxy-phenyl)-acetic acid,
Cyclohexyl-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-acetic acid,
[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-phenyl-acetic acid,
6-(2-Amino-1-phenyl-ethoxy)-N-(1-ethyl-pyrrolidin-2-ylmethyl)-N′-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4-diamine,
2-[4-[(1-Ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-2-phenyl-ethanol,
N-(1-Benzyl-pyrrolidin-2-ylmethyl)N′-cyclohexylmethyl-N″-(3-fluoro-4-methoxy-phenyl)-[1,3,5]triazine-2,4,6-triamine,
Amino-phenyl-acetic acid 4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-yl ester,
Trifluoro-acetate 2-{[4-(cyclohexylmethyl-amino)-6-(3-fluoro-4-methoxyphenylamino)-[1,3,5]triazin-2-ylamino]-methyl)-1-ethyl-pyrrolidinium, or
2-Cyclohexyl-2-[4-[(1-ethyl-pyrrolidin-2-ylmethyl)-amino]-6-(3-fluoro-4-methoxy-phenylamino)-[1,3,5]triazin-2-ylamino]-ethanol, or
a stereoisomer thereof, a salt thereof, or a combination thereof.
3. The composition as claimed in claim 2 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
4. The composition as claimed in claim a 2 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
5. A compound having the formula:
wherein
6. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 5 .
7. The composition as claimed in claim 6 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient or
any combination thereof.
8. A compound having the formula:
wherein
9. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 8 .
10. The composition as claimed in claim 9 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
11. A compound having the formula:
wherein
12. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 11 .
13. The composition as claimed in claim 12 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative; and
a pharmaceutically acceptable excipient; or
any combination thereof.
14. A compound having the formula:
wherein
15. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 14 .
16. The composition as claimed in claim 15 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
17. The composition as claimed in claim 2 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
18. The composition as claimed in claim 6 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
19. The composition as claimed in claim 9 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
20. The composition as claimed in claim 12 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
21. The composition as claimed in claim 15 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
22. A compound having the formula:
wherein
23. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 22 .
24. The composition as claimed in claim 23 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
25. The composition as claimed in claim 23 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.
26. A compound having the formula:
wherein
27. A composition comprising a pharmaceutically acceptable carrier and a compound according to claim 26 .
28. The composition as claimed in claim 27 , further comprising at least one of the following:
a pharmaceutically acceptable auxiliary;
a pharmaceutically acceptable preservative;
a pharmaceutically acceptable excipient; or
any combination thereof.
29. The composition as claimed in claim 27 , wherein the composition is in the form of a tablet, a capsule, a cachet, a powder, a granule, a solution, a suspension, an emulsion, a bolus, a lozenge, a suppository, a pessary, a tampon, a cream, a gel, a paste, a foam, a spray, an aerosol, a microcapsule, a liposome, a transdermal patch, a pastille, a paste, or a mouthwash.