Separation of cresol from mares' urine
View Patent ↗A method of separating cresol from mares' urine by pervaporation using pore-free polymeric silicone membranes in which starting urine solutions containing high-quality and -quantity conjugated estrogens with a reduced or substantially removed cresol content are provided which are advantageously suitable for obtaining natural mixtures of conjugated estrogens from pregnant mares' urine.
1. A method for separating cresol from pregnant mares' urine, comprising reducing the cresol content of an aqueous starting solution of pregnant mares' urine by pervaporation using a pore-free polymeric silicone membrane, by permeating cresol on to a permeate side of the membrane, wherein a permeate liquid is present on the permeate side of the membrane, and obtaining a treated pregnant mares' urine solution as a retentate containing a mixture of conjugated estrogens with reduced cresol content.
2. A method according to claim 1 , wherein the cresol content of an aqueous starting solution of pregnant mares' urine is reduced by pervaporation, by pumping the cresol-containing aqueous starting solution of pregnant mares' urine through a silicone tube acting as a pore-free polymeric membrane or through a module of hollow silicone fibers, with cresol being permeated on to the permeate side, wherein a permeate liquid is present on the permeate side of the membrane, and the treated pregnant mare's urine solution being obtained as a retentate containing a mixture of conjugated estrogens with reduced cresol content.
3. A method according to claim 1 , wherein the permeate liquid comprises water.
4. A method according to claim 1 , wherein the permeate liquid comprises an aqueous ethanolic solution.
5. A method according to claim 1 , wherein the cresol-receiving permeate liquid is replenished at intervals during the pervaporation.
6. A method according to claim 1 , wherein the permeate liquid is replenished continuously during the pervaporation.