Prevention of urogenital infections
View Patent ↗The invention provides hyaluronic acid compounds and derivatives thereof for preventing urogenital infections by a variety of pathogens, as well as compositions, articles and methods for treating and preventing urogenital infections.
1. A method for preventing or treating a vaginal infection in a mammal consisting of administering to a mammalian vagina an effective amount of a hyaluronic acid compound or a hyaluronic acid compound that is mixed or covalently linked to a non-polysaccharide polymer, or a salt thereof, wherein the hyaluronic acid compound or hyaluronic acid compound that is mixed or covalently linked to a non-polysaccharide polymer, or salt thereof, can inhibit adherence of Escherichia coli or Candida albicans to mammalian epithelial cells.
2. The method of claim 1 , wherein the hyaluronic acid compound or salt thereof prevents infection of pathogen in a mammalian vagina.
3. The method of claim 2 , wherein the pathogen is a bacterial, fungal or trichomonial pathogen.
4. The method of claim 2 , wherein the pathogen is Candida albicans.
5. The method of claim 2 , wherein the pathogen is Escherichia coli.
6. The method of claim 1 , wherein the hyaluronic acid compound or salt thereof comprises (β-1,4-)-linked D-glucuronic acid and (β1,3-)-N-acetyl-D-glucosamine.
7. The method of claim 1 , wherein the hyaluronic acid compound or salt thereof comprises one or more glucose, glucuronic acid, mannose, mannuronic acid, galactose, galacturonic acid, gulose, guluronic acid, fucose, xylose, N-acetylneuraminic acid, or N-acetyl glucosamine saccharide units.
8. The method of claim 1 , wherein the non-polysaccharide polymer is poly(ethylene glycol), poly(vinyl alcohol), poly(vinylpyrrolidone), or poly(2-hydroxylethyl methacrylate).
9. The method of claim 1 , wherein the hyaluronic compound acid or salt thereof comprises a repeating disaccharide unit of formula I:
wherein n is an integer of about 2 to about 100,000.
10. The method of claim 9 , wherein a lower alkyl replaces any of the hydrogen atoms from the hydroxy (—OH), carboxylic acid (—COOH) and methylenehydroxy (—CH 2 —OH) substituents within one or more of the disaccharide units of formula I.
11. The method of claim 9 , wherein an amino, a sulfate or a lower alkyl amino group replaces any of the OH groups from the hydroxy (—OH), carboxylic acid (—COOH) and methylenehydroxy (—CH 2 —OH) substituents within one or more of the disaccharide units of formula I.
12. The method of claim 1 , wherein the effective amount comprises about 0.01 milligrams to about 500 milligrams of hyaluronic acid compound or salt thereof.