Bone graft substitute composition
View Patent ↗A composition includes calcium sulfate hemihydrate, stearic acid, an accelerant, and a mixing solution. The composition can be injected, e.g., through a needle, and is capable of setting, e.g., in vivo, in a relatively short period of time to a relatively high hardness.
1. A kit, comprising:
a mixture comprising greater than 95 weight percent calcium sulfate hemihydrate coated with sucrose, about 0.1 to about 0.5 weight percent calcium sulfate dihydrate, and about 1.5 to about 2 weight percent of a binder selected from the group consisting of stearic acid, hydroxypropylmethylcellulose, and hydroxymethylcellulose; and an aqueous saline mixing solution.
2. A composition, comprising:
greater than 95 weight percent calcium sulfate hemihydrate;
about 0.1 to about 0.5 weight percent calcium sulfate dihydrate coated with sucrose;
about 1.5 to about 2 weight percent stearic acid; and
a aqueous saline mixing solution,
wherein the composition is capable of hardening to about 4 MPa within about 10 minutes.
3. The composition of claim 2 , wherein the composition is injectable.
4. The composition of claim 3 , wherein the composition is injectable through a 6 cm long, 11-gauge needle.
5. A composition, consisting essentially of:
greater than 95 weight percent calcium sulfate hemihydrate;
about 0.1 to about 0.5 weight percent calcium sulfate dihydrate coated with sucrose;
about 1.5 to about 2 weight percent of a binder selected from the group consisting of stearic acid, hydroxypropylmethylcellulose, and hydroxymethylcellulose;
and a aqueous saline mixing solution.
6. A method, comprising:
providing a mixture comprising:
>95 wt % of calcium sulfate hemihydrate;
about 0.1 to about 0.5 wt % of calcium sulfate dihydrate coated with sucrose;
and about 1.5 to about 2 wt % of stearic acid; and
contacting the mixture with a saline solution to form a composition.
7. The method of claim 6 , further comprising injecting the composition through a needle.