IP Library Granted Patent US 7,179,444
Granted Patent B2
US 7,179,444 · App. 10/405,094 · Granted Feb 20, 2007

Pendant fatty acid imaging agents

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Quick Facts
Patent No.
US 7,179,444
App. No.
10/405,094
Granted
Feb 20, 2007
Kind
B2
Abstract

The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.

Claims (21)

1. An imaging agent represented by the structure:

wherein

R 3 is selected from the group consisting of a hydrogen or methyl;

p is an integer selected from 0, 1, 2, 4, 6, or 8;

R 7 is a metal chelating moiety bound to a metallic carbonyl ligand;

wherein the stereochemical configuration of the imaging agent can be a R-stereoisomer or a S-stereoisomer or mixtures thereof at each stereocenter, and

pharmaceutically acceptable salts thereof.

2. A composition comprising the imaging agent of claim 1 , wherein the stereochemical configuration of the imaging agent is a R-stereoisomer and the composition is of more than about 75% isomeric purity.

3. A composition comprising the imaging agent of claim 1 , wherein the stereochemical configuration of the imaging agent is a S-stereoisomer and the composition is of more than about 75% isomeric purity.

4. The imaging agent of claim 1 , wherein R 3 is methyl.

5. The imaging agent of claim 1 , wherein the metallic carbonyl ligand is selected from a radionuclide carbonyl ligand or a rhenium-carbonyl ligand.

6. The imaging agent of claim 5 , wherein the radionuclide carbonyl ligand is a 99m Tc-carbonyl ligand.

7. The imaging agent of claim 1 , wherein the metallic carbonyl ligand comprises a low oxidation state metal.

8. A kit comprising the imaging agent of claim 1 and a pharmaceutically acceptable carrier.

9. A method of identifying a lesion, comprising administering to a patient a imaging agent of claim 1 .

10. The method of claim 9 , wherein the lesion is in the cardiovascular system.

11. The method of claim 10 , wherein the imaging agent has a high specificity for the myocardium.

12. An imaging agent of the formula:

13. A kit comprising the imaging agent of claim 12 and a pharmaceutically acceptable carrier.

14. A method of identifying a lesion, comprising administering to a patient an imaging agent of claim 12 .

15. The method of claim 11 , wherein the imaging agent has a high specificity for the myocardium.

Assignments (7)
RELEASE OF PATENT SECURITY INTEREST Recorded Jan 18, 2013
From: NEXBANK, SSB (AS COLLATERAL AGENT)
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 029660/0618 →
MERGER Recorded Jun 6, 2011
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 026396/0273 →
GRANT OF SECURITY INTEREST IN PATENT RIGHTS Recorded May 26, 2011
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: NEXBANK, SSB, A TEXAS-CHARTERED SAVINGS BANK, AS COLLATERAL AGENT
Reel/Frame 026347/0233 →
TERMINATION AND RELEASE OF GRANT OF SECURITY INTEREST IN PATENT RIGHTS Recorded May 23, 2011
From: THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (F/K/A THE BANK OF NEW YORK TRUST COMPANY, N.A.)
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 026328/0309 →
SECURITY AGREEMENT Recorded Nov 19, 2007
From: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
To: BANK OF NEW YORK TRUST COMPANY, N.A., THE
Reel/Frame 020143/0001 →
ARTICLES OF AMENDMENT Recorded Apr 27, 2005
From: BIOSTREAM, INC.
To: MOLECULAR INSIGHT PHARMACEUTICALS, INC.
Reel/Frame 016172/0194 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2004
From: BABICH, JOHN W.; MARESCA, KEVIN P.
To: BIOSTREAM, INC.
Reel/Frame 014426/0708 →