Pendant fatty acid imaging agents
View Patent ↗The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides for a method administering a imaging agent with a high specificity for the myocardium.
1. An imaging agent represented by the structure:
wherein
R 3 is selected from the group consisting of a hydrogen or methyl;
p is an integer selected from 0, 1, 2, 4, 6, or 8;
R 7 is a metal chelating moiety bound to a metallic carbonyl ligand;
wherein the stereochemical configuration of the imaging agent can be a R-stereoisomer or a S-stereoisomer or mixtures thereof at each stereocenter, and
pharmaceutically acceptable salts thereof.
2. A composition comprising the imaging agent of claim 1 , wherein the stereochemical configuration of the imaging agent is a R-stereoisomer and the composition is of more than about 75% isomeric purity.
3. A composition comprising the imaging agent of claim 1 , wherein the stereochemical configuration of the imaging agent is a S-stereoisomer and the composition is of more than about 75% isomeric purity.
4. The imaging agent of claim 1 , wherein R 3 is methyl.
5. The imaging agent of claim 1 , wherein the metallic carbonyl ligand is selected from a radionuclide carbonyl ligand or a rhenium-carbonyl ligand.
6. The imaging agent of claim 5 , wherein the radionuclide carbonyl ligand is a 99m Tc-carbonyl ligand.
7. The imaging agent of claim 1 , wherein the metallic carbonyl ligand comprises a low oxidation state metal.
8. A kit comprising the imaging agent of claim 1 and a pharmaceutically acceptable carrier.
9. A method of identifying a lesion, comprising administering to a patient a imaging agent of claim 1 .
10. The method of claim 9 , wherein the lesion is in the cardiovascular system.
11. The method of claim 10 , wherein the imaging agent has a high specificity for the myocardium.
12. An imaging agent of the formula:
13. A kit comprising the imaging agent of claim 12 and a pharmaceutically acceptable carrier.
14. A method of identifying a lesion, comprising administering to a patient an imaging agent of claim 12 .
15. The method of claim 11 , wherein the imaging agent has a high specificity for the myocardium.