Pyrimidine nucleotide precursors for treatment of systemic inflammation and inflammatory hepatitis
View Patent ↗Pyrimidine nucleotide precursors including acyl derivatives of cytidine, uridine, and orotate, and uridine phosphorylase inhibitors, and their use in enhancing resistance to sepsis or systemic inflammation are disclosed.
1. A method of treating cachexia comprising administering to an animal having cachexia a therapeutically effective amount of triacetyluridine.
2. A method as in claim 1 further comprising administering an inhibitor of uridine phosphorylase selected from the group consisting of 5-benzyl barbiturate, 5-benzyloxybenzyl barbiturate, 5-benzyloxybenzyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-benzyloxybenzylacetyl-1-[(1-hydroxy-2-ethoxy)methyl] barbiturate, 5-methoxybenzylacetylacyclobarbiturate, 2,2′-anhydro-5-ethyluridine, benzylacyclouridine, benzyloxybenzylacyclouridine, aminomethyl-benzylacyclouridine, aminomethylbenzyloxybenzylacyclouridine, hydroxymethylbenzylacyclouridine and hydroxymethyl-benzyloxybenzylacyclouridine.