Intra-aortic renal drug delivery catheter
View Patent ↗A catheter for delivering a therapeutic or diagnostic agent to a branch blood vessel of a major blood vessel, generally comprising an elongated shaft having at least one lumen in fluid communication with an agent delivery port in a distal section of the shaft, an expandable tubular member on the distal section of the shaft, and a radially expandable member on the tubular member. The tubular member is configured to extend within the blood vessel up-stream and down-stream of a branch vessel, and has an interior passageway which is radially expandable within the blood vessel to separate blood flow through the blood vessel into an outer blood flow stream exterior to the tubular member and an inner blood flow stream within the interior passageway of the tubular member.
1. A method for enhancing renal function in a patient, comprising:
separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;
injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;
wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and
wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of nifedipine.
2. The method of claim 1 , wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.
3. The method of claim 1 , wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.
4. The method of claim 3 , wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.
5. The method of claim 3 , further comprising inflating the tubular member.
6. A method for enhancing renal function in a patient, comprising:
separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;
injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;
wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and
wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of Verapamil.
7. The method of claim 6 , wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.
8. The method of claim 6 , wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.
9. The method of claim 8 , wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.
10. The method of claim 8 , further comprising inflating the tubular member.
11. A method for enhancing renal function in a patient, comprising:
separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;
injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;
wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and
wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of Fenoldopam.
12. The method of claim 11 , wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.
13. The method of claim 11 , wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.
14. The method of claim 13 , wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.
15. The method of claim 13 further comprising inflating the tubular member.
16. A method for enhancing renal function in a patient, comprising:
separating a portion of aortic blood flowing into a location within an abdominal aorta into a first blood flow stream that flows along a first flow path substantially only into a plurality of renal arteries via a plurality of respective ostia having unique respective locations along the abdominal aorta wall and a second blood flow stream that flows along a second flow path across the renal artery ostia and into downstream circulation;
injecting a volume of fluid agent into the first flow path within the abdominal aorta at the location;
wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via the first flow path into their respective ostia while the second blood flow stream flows along the second flow path across the renal artery ostia and into downstream circulation; and
wherein the fluid agent being delivered into the plurality of renal arteries comprises a volume of a dopamine DA 1 agonist.
17. The method of claim 16 , wherein the injected fluid agent is delivered substantially only into the plurality of renal arteries via their respective ostia simultaneously.
18. The method of claim 16 , wherein the first flow path passes exterior to a tubular member, and the second blood flow path passes within an interior passageway of the tubular member.
19. The method of claim 18 , wherein the tubular member tapers from a larger diameter downstream end to a smaller diameter upstream end.
20. The method of claim 18 , further comprising inflating the tubular member.