Absorbable implantable vaso-occlusive member
View Patent ↗Compositions comprising absorbable implantable vaso-occlusive members are described. Also described are methods of making and using these absorbable vaso-occlusive compositions.
1. A vaso-occlusive member comprising:
(i) an absorbable material having a three-dimensional configuration, the three-dimensional configuration having two ends and a longitudinal exterior surface extending between the two ends, wherein the absorbable material is detachably connected to a core wire; and
(ii) one or more stretch-resistant members fixedly attached to at least two locations of the absorbable material, wherein one or more of the stretch-resistant members extend over most or all of the longitudinal exterior surface of the absorbable material.
2. The vaso-occlusive member of claim 1 , wherein the vaso-occlusive member has a configuration selected from the group consisting of J-shaped, straight, cylindrical, spherical, tube-like, and helical coil.
3. The vaso-occlusive member of claim 2 , wherein the absorbable material is configured as a helical coil having a plurality of helical winds, a first end, a second end and lumen between said first and second ends.
4. The vaso-occlusive member of claim 3 , wherein the stretch-resistant member is threaded through the winds of said coil.
5. The vaso-occlusive member of claim 3 , wherein the stretch-resistant member is attached to the interior or exterior of the helical coil.
6. The vaso-occlusive member of claim 1 , wherein the stretch-resistant member is absorbable.
7. The vaso-occlusive member of claim 1 , wherein the stretch-resistant member is non-absorbable.
8. The vaso-occlusive member of claim 1 , wherein the absorbable material is selected from the group consisting of polyglygolic acid (PGA), poly-glycolic/poly-L-lactic acid co-polymers, polycaprolactone, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide, polydioxanone, polycarbonates, polyanhydrides, collagen, elastin, fibrinogen, fibronectin, vitronectin, laminin, gelatin and combinations thereof.
9. The vaso-occlusive member of claim 1 , wherein the stretch-resistant member is a mono-filament.
10. The vaso-occlusive member of claim 9 , wherein the mono-filament comprises polypropylene.
11. The vaso-occlusive member of claim 1 , wherein the stretch-resistant member is a multi-filament.
12. The vaso-occlusive member of claim 1 , further comprising a deployment tip.
13. The vaso-occlusive member of claim 12 , wherein the deployment tip comprises an electrolytically detachable end adapted to detach from a pusher by imposition of a current on said pusher.
14. The vaso-occlusive member of claim 1 , further comprising a radio-opaque material.
15. The method of claim 14 , wherein the radio-opaque material is selected from the group consisting of powdered tantalum, powdered tungsten, bismuth oxide, and barium sulfate.
16. The vaso-occlusive member of claim 1 , further comprising a bioactive material.
17. A method for producing a vaso-occlusive member according to claim 1 , the method comprising the steps of:
(i) preparing a generally linear primary element comprising an absorbable material;
(ii) winding said primary element onto a mandrel;
(iii) heating said mandrel and said primary element to produce a three-dimensional member; and
(iv) fixedly attaching one or more stretch-resistant members to two or more locations of the three-dimensional member such that one or more of the stretch-resistant members extend over most or all of the longitudinal exterior surface of the three-dimensional member.
18. The method of claim 17 , wherein the vaso-occlusive member has a three-dimensional configuration comprising a helical coil.
19. The method of claim 17 , wherein the vaso-occlusive member has a three-dimensional configuration comprising a conical or spiral shape.
20. The method of claim 17 , wherein step (iii) comprises an approximately 15 minute heating step at approximately 165° C.
21. The method of claim 17 , wherein the mandrel comprises stainless steel.
22. The method of claim 17 , wherein the vaso-occlusive member further comprises at least one radio-opaque material.
23. The method of claim 22 , wherein the radio-opaque material is selected from the group consisting of powdered tantalum, powdered tungsten, bismuth oxide, and barium sulfate.
24. The method of claim 17 , wherein the vaso-occlusive member further comprises at least one bioactive material.
25. The vaso-occlusive device of claim 1 , further comprising a lubricious material.
26. The vaso-occlusive device of claim 25 , wherein the lubricious material is coated onto the device.
27. A vaso-occlusive member comprising
(i) an absorbable material configured as a tube; and
(ii) one or more stretch-resistant members fixedly attached to at least two locations of the tube, wherein one or more of the stretch-resistant members extend over most or all of the longitudinal exterior surface of the tube.
28. The vaso-occlusive member of claim 27 , wherein the tube comprises a plurality of perforations therein.
29. The vaso-occlusive member of claim 28 , wherein the stretch-resistant member is threaded through at least two of said perforations.
30. The vaso-occlusive member of claim 27 , wherein the stretch-resistant member is attached to the interior or exterior of the tube.
31. A method for producing a vaso-occlusive member according to claim 27 , the method comprising the steps of
(i) preparing a tube-like structure comprising an absorbable material; and
(ii) fixedly attaching one or more stretch-resistant members to two or more locations of the tube.
32. The method of claim 31 , wherein the preparing comprises micro-machining.
33. The method of claim 17 or claim 31 , wherein the absorbable material is selected from the group consisting of polyglygolic acid (PGA), poly-glycolic/poly-L-lactic acid co-polymers, polycaprolactone, polyhydroxybutyrate/hydroxyvalerate copolymers, poly-L-lactide, polydioxanone, polycarbonates, polyanhydrides, collagen, elastin, fibrinogen, fibronectin, vitronectin, laminin, gelatin and combinations thereof.
34. The method of claim 17 or claim 31 , further comprising the step of connecting two or more locations of the vaso-occlusive member to form one or more stretch-resistant members.
35. The method of claim 34 , wherein the connections are formed by heating or soldering the two or more locations to one another.
36. The method of claim 34 , wherein the stretch-resistant member is absorbable.
37. The method of claim 34 , wherein the stretch-resistant member is non-absorbable.
38. The method of claim 34 , wherein the stretch-resistant member is a mono-filament.
39. The method of claim 38 , wherein the mono-filament comprises polypropylene.
40. The method of claim 34 , wherein the stretch-resistant member is a multi-filament.
41. The method of claim 34 , wherein the stretch-resistant member is knotted to the vaso-occlusive member.
42. The method of claim 34 , wherein the stretch-resistant member is soldered to the vaso-occlusive member.