Optical resonance analysis system
View Patent ↗An optical resonance analysis system comprising a sensor means ( 60 ) and an illumination means ( 400 ) for generating non-monochromatic illumination. The illumination means ( 400 ) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles ( 390 ) and a dispersive device ( 380 ) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean ( 60 ) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means ( 90 ) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means ( 120 ).
1. An optical resonance analysis system comprising:
an illumination system for generating illumination of fixed multiple wavelengths comprising:
an array of elements each generating a different fixed wavelength; and
an optical system which projects said illumination of fixed wavelengths; and
a detection system comprising:
a sensor on which said illumination impinges which reflects or transmits said illumination; and,
a detector adapted to detect said reflected or transmitted illumination.
2. The optical resonance analysis system of claim 1 , wherein said sensor comprises a surface plasmon resonance device.
3. The optical resonance analysis system of claim 2 , wherein said sensor comprises a waveguide device.
4. The optical resonance analysis system of claim 2 , wherein said sensor comprises a multi-layered waveguide device.
5. The optical resonance analysis system of claim 2 , wherein said sensor is arranged as a one-dimensional array of analysis sites.
6. The optical resonance analysis system of claim 2 , wherein said sensor is arranged as a two-dimensional array of analysis sites.
7. The optical resonance analysis system of claim 2 , wherein said detector comprises a charge coupled device camera.
8. The optical resonance analysis system of claim 2 , wherein said detector comprises a charge injection device camera.
9. The optical resonance analysis system of claim 2 , wherein said detection system further comprises an angle stop.
10. The optical resonance analysis system of claim 2 , wherein said detection system further comprises a wavelength stop.
11. The optical resonance analysis system of claim 2 , wherein said detection system further comprises an imaging lens.
12. The optical resonance analysis system of claim 2 , wherein said detection system further comprises a polarizer.
13. An optical resonance analysis system comprising:
an illumination system for generating illumination of varying angles comprising:
a source comprising of an array of elements for generating illumination at a plurally of fixed angles; and
a lens system for projecting said illumination at said plurality of fixed angles; and
a detection system comprising:
a sensor on which said illumination impinges which reflects or transmits said illumination; and,
a detector adapted to detect said reflected or transmitted illumination.
14. The optical resonance analysis system of claim 13 , wherein said sensor comprises a surface plasmon resonance device.
15. The optical resonance analysis system of claim 13 , wherein said sensor comprises a waveguide device.
16. The optical resonance analysis system of claim 13 , wherein said sensor comprises a multi-layered waveguide device.
17. The optical resonance analysis system of claim 13 , wherein said sensor is arranged as a one-dimensional array of analysis sites.
18. The optical resonance analysis system of claim 13 , wherein said sensor is arranged as a two-dimensional array of analysis sites.
19. The optical resonance analysis system of claim 13 , wherein said detector comprises a charge coupled device camera.
20. The optical resonance analysis system of claim 13 , wherein said detector comprises a charge injection device camera.
21. The optical resonance analysis system of claim 13 , wherein said detection system further comprises an angle stop.
22. The optical resonance analysis system of claim 13 , wherein said detection system further comprises a wavelength stop.
23. The optical resonance analysis system of claim 13 , wherein said detection system further comprises an imaging lens.
24. The optical resonance analysis system of claim 13 , wherein said detection system further comprises a polarizer.
25. An optical resonance analysis system comprising:
a sensor;
an illumination system for generating non-monochromatic illumination having a plurality of wavelengths comprising:
a source for generating illumination at a plurality of angles;
a lens system for projecting said illumination at said plurality of angles; and
a dispersive device which disperses said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor for all wavelengths generated by said non-monochromatic source simultaneously;
a detector adapted to detect said reflected or transmitted illumination.
26. The optical resonance analysis system of claim 25 , wherein said sensor comprises a surface plasmon resonance device.
27. The optical resonance analysis system of claim 25 , wherein said sensor comprises a waveguide device.
28. The optical resonance analysis system of claim 25 , wherein said sensor further comprises a multi-layered waveguide device.
29. The optical resonance analysis system of claim 25 , wherein said sensor is arranged as a one-dimensional array of analysis sites.
30. The optical resonance analysis system of claim 25 , wherein said sensor is arranged as a two-dimensional array of analysis sites.
31. The optical resonance analysis system of claim 25 , wherein said detector comprises a charge coupled device camera.
32. The optical resonance analysis system of claim 25 , wherein said detector comprises a charge injection device camera.
33. The optical resonance analysis system of claim 25 , wherein said detector comprises an angle stop.
34. The optical resonance analysis system of claim 25 , wherein said detector comprises a wavelength stop.
35. The optical resonance analysis system of claim 25 , wherein said detector comprises an imaging lens.
36. The optical resonance analysis system of claim 25 , wherein said detector comprises a polarizer.
37. An optical resonance analysis system comprising:
an illumination system for generating illumination comprising:
a source; and
a system adapted to independently position said source rotationally and axially; and
a detection system comprising:
a sensor on which said illumination impinges which reflects or transmits said illumination; and,
a detector adapted to detect said reflected or transmitted illumination.
38. The optical resonance analysis system of claim 37 , wherein said sensor comprises a surface plasmon resonance device.
39. The optical resonance analysis system of claim 37 , wherein said sensor comprises a waveguide device.
40. The optical resonance analysis system of claim 37 , wherein said sensor comprises a multi-layered waveguide device.
41. The optical resonance analysis system of claim 37 , wherein said sensor is arranged as a one-dimensional array of analysis sites.
42. The optical resonance analysis system of claim 37 , wherein said sensor is arranged as a two-dimensional array of analysis sites.
43. The optical resonance analysis system of claim 37 , wherein said detector comprises a charge coupled device camera.
44. The optical resonance analysis system of claim 37 , wherein said detector comprises a charge injection device camera.
45. The optical resonance analysis system of claim 37 , wherein said detection system further comprises an angle stop.
46. The optical resonance analysis system of claim 37 , wherein said detection system further comprises a wavelength stop.
47. The optical resonance analysis system of claim 37 , wherein said detection system further comprises an imaging lens.
48. The optical resonance analysis system of claim 37 , wherein said detection system further comprises a polarizer.
49. The optical resonance analysis system of claim 37 , wherein said system comprises:
a housing;
a rotation mechanism adapted to rotate said source
a cylinder having pseudo-helical slots; and
pins extending from said rotation mechanism to engage said pseudo-helical slots.
50. An optical resonance analysis system comprising:
an illumination system for generating illumination;
an anamorphic imaging system;
a sensor on which said illumination impinges which reflects or transmits said illumination; and,
a detector adapted to detect said reflected or transmitted illumination.
51. The optical resonance analysis system of claim 50 , wherein said sensor comprises a surface plasmon resonance device.
52. The optical resonance analysis system of claim 50 , wherein said sensor comprises a waveguide device.
53. The optical resonance analysis system of claim 50 , wherein said sensor comprises a multi-layered waveguide device.
54. The optical resonance analysis system of claim 50 , wherein said sensor is arranged as a one-dimensional array of analysis sites.
55. The optical resonance analysis system of claim 50 , wherein said sensor is arranged as a two-dimensional array of analysis sites.
56. The optical resonance analysis system of claim 50 , wherein said sensor comprises a charge coupled device camera.
57. The optical resonance analysis system of claim 50 , wherein said sensor comprises a charge injection device camera.
58. The optical resonance analysis system of claim 50 , wherein said sensor comprises an angle stop.
59. The optical resonance analysis system of claim 50 , wherein said sensor comprises a wavelength stop.
60. The optical resonance analysis system of claim 50 , wherein said sensor comprises an imaging lens.
61. The optical resonance analysis system of claim 50 , wherein said sensor comprises a polarizer.
62. A system comprising:
an illumination system adapted to generate illumination having a plurality of wavelengths comprising:
a source adapted to generate the illumination at a plurality of angles; and
a dispersive device adapted to disperse the illumination; and
a sensor adapted to receive illumination from the illumination system and to image light to the detector at a plurality of angles;
a detector adapted to detect the light from the sensor;
wherein the sensor is adapted to generate surface plasmon resonance dispersion that provides a correlation between the plurality of angles and the plurality of wavelengths.
63. The system of claim 62 , wherein said surface plasmon resonance is generated substantially simultaneously for each wavelength of the plurality of wavelengths.
64. The system of claim 62 , wherein the light imaged by the sensor is reflected illumination.
65. The system of claim 62 , wherein the light imaged by the sensor is transmitted illumination.
66. The system of claim 62 , wherein the sensor comprises a plurality of active sites.
67. The system of claim 66 , wherein the sensor comprises a plurality of gaps between the active sites.
68. The system of claim 67 , wherein the illumination system is adapted to reduce the width of the gaps.
69. The system of claim 68 , wherein the detector comprises a plurality of zones.
70. The system of claim 69 , wherein the light is imaged from one active site of the plurality of active sites to one zone of the plurality of zones.
71. The system of claim 70 , wherein the detector comprises a detection sensitivity.
72. The system of claim 71 , wherein reducing the width of the gaps increases detection sensitivity.
73. The system of claim 62 , wherein the dispersive device comprises a dispersion grating.
74. The system of claim 73 , wherein the dispersion grating is an anti-correlation grating.
75. The system of claim 62 , wherein the dispersive device is adapted to accentuate the surface plasmon resonance dispersion.
76. The system of claim 62 , further comprising a lens system adapted to project the illumination at a plurality of angles.
77. The system of claim 62 , wherein said source comprises an angle scanning device.
78. A method for detection comprising:
providing illumination at a plurality of wavelengths;
scanning the illumination at a plurality of angles;
pre-dispersing the illumination;
dispersing the illumination by surface plasmon resonance;
detecting the illumination;
wherein the pre-dispersing accentuates the dispersing by the surface plasmon resonance.
79. The method of claim 78 , further comprising projecting the illumination at a plurality of angles.
80. The method of claim 78 , wherein dispersing comprises reflecting the illumination.
81. The method of claim 78 , wherein dispersing comprises transmitting the illumination.