Solvates and polymorphs of ritonavir and methods of making and using the same
View Patent ↗Novel solvates and crystal polymorphs of Ritonavir are disclosed, as well as methods of making them. Specific solvates of the compound include a formamide solvate and a partially desolvated solvate. Also disclosed are methods of making previously known forms of Ritonavir. Methods of using the novel forms of Ritonavir for the treatment of diseases, such as HIV-infection, are disclosed, as are pharmaceutical compositions and unit dosage forms comprising the novel forms of Ritonavir.
1. Ritonavir Form III characterized by a melting point from about 78° C. to about 82° C. and by a powder X-ray diffraction pattern containing peaks at 3.1, 6.8, 7.7, 8.3, 9.2, 10.5, 12.1, and 13.1 degrees 2-Theta.
2. The Form III of claim 1 , wherein said Form III is further characterized by a Raman spectra with peaks at 691.1 and 1393.3 cm −1 .
3. Ritonavir Form IV characterized by a melting point from about 97° C. to about 101° C. and by a powder X-ray diffraction pattern containing peaks at 3.1, 6.1, 9.2, 12.1, and 13.8 degrees 2-Theta.
4. The Form IV of claim 3 , wherein said Form IV is further characterized by a Raman spectra with a peak at 1404.7 cm −1 .
5. Ritonavir Form V characterized by a melting point from about 114° C. to about 118° C. and by a powder X-ray diffraction pattern containing peaks at 3.4, 6.4, 9.9, 12.7, 13.6, 15.3, 15.8, and 17.5 degrees 2-Theta.
6. The Form V of claim 5 , wherein said Form V is further characterized by a Raman spectra with peaks at 814.6 and 963.7 cm −1 .