Antimicrobial theta defensins, analogs thereof, and methods of use
View Patent ↗The invention provides theta defensin analogs having antimicrobial activity. The invention also provides a method of reducing or inhibiting growth or survival of a microorganism in an environment capable of sustaining the growth or survival of the microorganism, comprising administering an effective amount of a theta defensin analog to the environment, thereby reducing or inhibiting the growth or survival of the microorganism.
1. A theta defensin analog comprising SEQ ID NO:25.
2. A pharmaceutical composition, comprising the theta defensin analog of claim 1 and a pharmaceutically acceptable carrier.
3. A method of reducing or inhibiting growth or survival of a microorganism in an environment capable of sustaining the growth or survival of the microorganism, comprising administering an effective amount of the theta defensin analog claim 1 to said environment, thereby reducing or inhibiting of the growth or survival of the microorganism.
4. The method of claim 3 , wherein said environment is a food or food product.
5. The method of claim 3 , wherein said environment is a solution.
6. The method of claim 5 , wherein said solution is a contact lens solution.
7. The method of claim 5 , wherein said solution is an eye wash solution.
8. The method of claim 3 , wherein said environment is an inanimate object comprising a surface.
9. The method of claim 3 , wherein said environment is a mammal.
10. The method of claim 3 , wherein said administration is topical.
11. The method of claim 3 , wherein said administration is by injection.
12. The method of claim 3 , wherein said administration is oral.