Methods for flow augmentation in patients with occlusive cerebrovascular disease
The invention provides a method for augmenting circulation in a patient having carotid stenosis. An elongate tubular member is provided having a lumen communicating with a port at a distal end. The tubular member is inserted into a peripheral artery and the distal port is advanced into a first carotid artery substantially free of a lesion where the patient possesses a second carotid artery substantially occluded by a lesion. Blood is perfused into the first carotid artery through the tubular member. Contralateral flow is augmented to improve perfusion to an ischemic region distal to the carotid stenosis. Angioplasty and stenting can be used to open the lesion in the second carotid artery.
1. A method for augmenting circulation in a patient having a vascular lesion, comprising the steps of:
providing an elongate tubular member having a lumen communicating with a port at a distal end;
inserting the tubular member into a peripheral artery and advancing the distal port into a first cerebral or carotid artery substantially free of a lesion, wherein the patient possesses a second cerebral or carotid artery substantially occluded by a lesion; and
perfusing blood into the first cerebral or carotid artery through the tubular member, wherein contralateral flow is augmented to improve perfusion to an ischemic region distal to the lesion by retrograde blood flow within the second cerebral or carotid artery.
2. The method of claim 1 , wherein a proximal end of the tubular member is attached to a pump.
3. The method of claim 1 , wherein blood is aspirated from an artery and filtered before perfusion into the carotid artery.
4. The method of claim 1 , wherein the lesion is located in the internal carotid artery.
5. The method of claim 1 , wherein the lesion is located in the middle cerebral artery.
6. The method of claim 1 , wherein the tubular member further includes a manometer carried at the distal end.
7. The method of claim 1 , wherein the tubular member further includes an expandable occlusive member carried proximal to the distal port.
8. The method of claim 7 , wherein the step of inserting the tubular member into an artery further comprises the step of expanding the occlusive member.
9. The method of claim 7 , wherein the step of advancing the port of the tubular member into the carotid artery further comprises the step of expanding the occlusive member.
10. The method of claim 1 , wherein the blood perfused into the carotid artery is hypothermic.
11. The method of claim 1 , wherein the port and lumen of the tubular member are adapted for infusion of fluid and pharmaceutical agents.
12. The method of claim 11 , wherein the pharmaceutical agent is a neuroprotective agent.
13. The method of claim 11 , wherein the pharmaceutical agent is heparin.
14. The method of claim 1 , further comprising the steps of inserting a second tubular member into an artery and aspirating blood from the artery through the second tubular member.
15. The method of claim 1 , wherein the lesion is a stenosis, thrombus, and/or emboli.
16. The method of claim 1 , further comprising the step of performing an angioplasty procedure in the second carotid artery to open the lesion.
17. The method of claim 1 , further comprising the step of placing a stent in the second carotid artery to open the lesion.
18. A method for augmenting circulation in a patient having carotid stenosis, comprising the steps of:
providing a first elongate tubular member having a lumen communicating with a port at a distal end;
providing a second elongate tubular member having a lumen communicating with a port at a distal end;
inserting the first tubular member into a peripheral artery;
inserting the second tubular member into the peripheral artery and advancing the distal port into a first carotid artery substantially free of a lesion, wherein the patient possesses a second carotid artery substantially occluded by a lesion; and
perfusing blood into the first carotid artery through the second tubular member, wherein contralateral flow is augmented to improve perfusion to an isehemic region distal to the lesion by retrograde blood flow within the second carotid artery.