IP Library › Granted Patent US 6,878,827
Granted Patent B2
US 6,878,827 · App. 10/432,605 · Granted Apr 12, 2005

Process for producing anhydride of aminothiazole derivative

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Quick Facts
Patent No.
US 6,878,827
App. No.
10/432,605
Granted
Apr 12, 2005
Kind
B2
Abstract

This invention provides a novel industrial process for preparation of an anhydride of 2-(2-aminothiazole-4-yl)-2-hydroxy compound.

Claims (6)

1. A process for preparation of a compound represented by the formula (I) in anhydrous form:

in which R 1 is acyl, protected carboxy(lower)alkyl or alkyl, comprising treating a hydrate of 2-(2-aminothiazole-4-yl)-2-hydroxy compound represented by the formula (I) in a ketone or acetonitrile.

2. The process of claim 1 , wherein R 1 is acyl.

3. The process of claim 1 , wherein R 1 is protected carboxy(lower)alkyl.

4. The process of claim 1 , wherein R 1 is alkyl.

5. The process of claim 1 , wherein the hydrate is a syn-isomer.

Assignments (2)
MERGER Recorded Dec 12, 2005
From: FUJISAWA PHARMACEUTICAL CO., LTD.
To: ASTELLAS PHARMA INC.
Reel/Frame 017073/0257 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 14, 2003
From: ONO, HIROKI; HAYASHI, MASARU; OHNISHI, MASARU; OHKAWA, KAZUO; KITAYAMA, MASATO
To: FUJISAWA PHARMACEUTICAL CO., LTD.
Reel/Frame 014589/0331 →