1,4,5.6-tetrahydroimidazo[4,5-d]diazepine derivatives or salts thereof
View Patent ↗To provide a compound having a superior arginine vasopressin antagonism. A novel 1,4,5,6-tetrahydroimidazo[4,5-d]benzazepine derivative or a pharmaceutically acceptable salt thereof.
1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein the ring D represents phenylene or pyridinediyl; X and Y may be the same or different and each represents CH or N; and R 1 , R 2 and R 3 may be the same or different and each represents a hydrogen atom, a hydroxyl group, a halogen, or a lower alkyl.
2. The compound or its pharmaceutically acceptable salt according to claim 1 , wherein the ring D represents 1,4-phenylene, pyridine-2,5-diyl, or pyridine-3,6-diyl.
3. The compound or its pharmaceutically acceptable salt according to claim 2 , wherein X and Y each represents OH, and R 1 represents a hydrogen atom.
4. The compound or its pharmaceutically acceptable salt according to claim 3 , wherein the ring D represents 1,4-phenylene, and R 2 and R 3 each represents a hydrogen atom.
5. The compound or its pharmaceutically acceptable salt according to claim 1 , wherein the compound is
N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
N-{3-fluoro-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
2′-fluoro-N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
N-{5-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-2-pyridyl}biphenyl-2-carboxamide,
N-{6-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-3-pyridyl}biphenyl-2-carboxamide, or
N-{2-hydroxy-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide.
6. A composition comprising the compound or its pharmaceutically acceptable salt according to any one of claims 1 to 5 , and a pharmaceutical carrier or excipient.
7. A composition comprising a compound or its pharmaceutically acceptable salt, and a pharmaceutical carrier or excipient, wherein the compound is
N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
N-{3-fluoro-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
2′-fluoro-N-{4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide,
N-{5-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-2-pyridyl}biphenyl-2-carboxamide,
N-{6-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]-3-pyridyl}biphenyl-2-carboxamide, or
N-{2-hydroxy-4-[2-(2-pyridyl)-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine-6-carbonyl]phenyl}biphenyl-2-carboxamide.